{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T17:06:54Z","timestamp":1786554414728,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T00:00:00Z","timestamp":1540857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the intraobserver and interobserver reproducibility of a novel sonographic parameter named facial maxillary angle (FMA) and to establish nomograms of FMA, inferior facial angle (IFA), frontal nasal\u2010mental angle (FNMA), maxilla\u2010nasion\u2010mandible angle (MNMA), and fetal profile line (FPL) in Chinese fetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective cross\u2010sectional study, FMA, IFA, FNMA, MNMA, and FPL were measured in 592 normal fetuses between 16 and 36 gestational weeks. FMA was measured twice by the same and another operator with a blinded method on the first 50 cases. The reference interval was defined as \u00b12<jats:italic>SD<\/jats:italic>. The efficacy of five sonographic markers was tested in 10 fetuses with micrognathia retrieved from the database of our unit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The intraclass correlation coefficient (95% CI) of intraobserver and interobserver reproducibility of FMA was 0.937 (0.890\u20100.964) and 0.891 (0.809\u20100.938), respectively. FMA, FNMA, and IFA increased slightly from 16\u00a0weeks till 28\u201031\u00a0weeks and decreased minimally thereafter. FMA and FNMA made correct diagnosis in all affected fetuses; MNMA and IFA identified nine and eight cases respectively, and FPL only detected five cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A fixed cutoff of 66\u00b0 for FMA and 136\u00b0 for FNMA may be adopted as simple screening criteria of micrognathia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5371","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T10:07:34Z","timestamp":1539770854000},"page":"107-115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Objective assessment of the fetal facial profile at second and third trimester of pregnancy"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1387-3700","authenticated-orcid":false,"given":"Jing","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Chinese University of Hong Kong, Prince of Wales Hospital  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3755-2701","authenticated-orcid":false,"given":"Daljit Singh","family":"Sahota","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Chinese University of Hong Kong, Prince of Wales Hospital  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liona C.","family":"Poon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Chinese University of Hong Kong, Prince of Wales Hospital  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuen Ha","family":"Ting","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Chinese University of Hong Kong, Prince of Wales Hospital  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne Kwun Yue","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Chinese University of Hong Kong, Prince of Wales Hospital  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Peking University Shen Zhen hospital  Shen Zhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tak Yeung","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Chinese University of Hong Kong, Prince of Wales Hospital  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1299482"},{"issue":"4","key":"e_1_2_8_3_1","first-page":"340","article-title":"Universal prenatal chromosomal microarray analysis: additive value and clinical dilemmas in fetuses with a normal karyotype","volume":"34","author":"Bornstein E","year":"2017","journal-title":"Am J Perinatol"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.07.016"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.acc.2016.05.004"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0000000000000347"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3943"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7639"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8831"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000263740"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0960-7692.2001.00622.x"},{"key":"e_1_2_8_12_1","first-page":"121","article-title":"An objective measurement to diagnose micrognathia on prenatal ultrasound","volume":"35","author":"Palit G","year":"2008","journal-title":"Clin Exp Obstet Gynecol"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7768"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3904"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1991.01010012.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-994725"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-994125"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-199903000-00014"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2003.07.031"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000082436"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1363"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3866"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2482"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7441"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00056-014-0257-1"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10058"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6252"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1993.03060378.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780121003"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19971230)16:24<2785::AID-SIM797>3.0.CO;2-Z"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780100502"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.03.059"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5288"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7745"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1998.11010030.x"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp\/books\/11294"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1597\/10-238"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2661"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0889-5406(87)90366-0"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0889-5406(91)70114-C"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1597\/09-221"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2012.31.4.569"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.5371","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.5371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T07:06:46Z","timestamp":1694329606000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.5371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,30]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1002\/pd.5371"],"URL":"https:\/\/doi.org\/10.1002\/pd.5371","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,30]]},"assertion":[{"value":"2018-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}