{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:45:51Z","timestamp":1790660751241,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T00:00:00Z","timestamp":1541462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002020","name":"Children's Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002020","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["(K23\u2010063371)"],"award-info":[{"award-number":["(K23\u2010063371)"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["K23\u2010063371"],"award-info":[{"award-number":["K23\u2010063371"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR000130"],"award-info":[{"award-number":["UL1TR000130"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL128818\u201003"],"award-info":[{"award-number":["R01 HL128818\u201003"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Anomalous neurological development associated with congenital heart disease (CHD) has been reported as early as third trimester of fetal development. While several studies have characterized variations in CHD neurodevelopmental outcomes in early childhood, these reports are often confounded by postnatal factors such as surgical outcome. Recent studies have focused on the comparing neurological variations between fetuses with CHD and normal controls. In this work, we present a comparison of in utero variations in brain development between fetuses with different types of CHD, by analyzing them under categories of single ventricle versus biventricular cardiac anatomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using recent advances in fetal magnetic resonance imaging (MRI), we quantify the volumetric trajectories of various brain tissues (such as cortical plate, developing white matter, cerebrospinal fluid [CSF], and cerebellum).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our study is the first to differentiate between intraventricular and extra\u2010axial CSF thereby allowing us to better identify variations in brain composition of the fetuses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, our findings show that while total brain volume is similar between fetuses with single and biventricular anatomy, they exhibit statistically significant disparity in brain composition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.5374","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T08:27:55Z","timestamp":1539764875000},"page":"1042-1048","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Fetuses with single ventricle congenital heart disease manifest impairment of regional brain growth"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7871-6768","authenticated-orcid":false,"given":"Vidya","family":"Rajagopalan","sequence":"first","affiliation":[{"name":"Department of Radiology Children's Hospital Los Angeles  Los Angeles California"},{"name":"Rudi Schulte Research Institute  Santa Barbara California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodie K.","family":"Votava\u2010Smith","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology Children's Hospital Los Angeles  Los Angeles California"},{"name":"Keck University School of Medicine University of Southern California  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Southern California  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Brian","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Southern California  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lila","family":"Marshall","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Southern California  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Panigrahy","sequence":"additional","affiliation":[{"name":"Department of Pediatric Radiology Children's Hospital Pittsburgh of UPMC  Pittsburgh Pennsylvania"},{"name":"University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Paquette","sequence":"additional","affiliation":[{"name":"Keck University School of Medicine University of Southern California  Los Angeles California"},{"name":"Department of Pediatrics, Division of Neonatology Children's Hospital Los Angeles  Los Angeles 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