{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:57:32Z","timestamp":1790564252150,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2018,12,16]],"date-time":"2018-12-16T00:00:00Z","timestamp":1544918400000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The study aims to describe our two\u2010dimensional (2D) ultrasound approach to visualize the fetal secondary palate and plot its growth curve and to describe and demonstrate its clinical implementation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a two parts retrospective study. First, we measured the antero\u2010posterior length of the bony secondary palate, from the <jats:italic>soft to hard palate interface<\/jats:italic> (SHPI) line to the alveolar ridge, blindly by two operators during routine scans of low\u2010risk fetuses, and plot a longitudinal growth curve. In the second part, we describe four cases of prenatal diagnosis of secondary palate cleft.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010eight fetuses were included: 14 to 15\u00a0weeks (n\u00a0=\u00a020), 21 to 24\u00a0weeks (n\u00a0=\u00a032), and 29 to 35\u00a0weeks (n\u00a0=\u00a016). The bony secondary palate elongates along gestation from a mean of 5.3\u00a0mm (+\/\u22120.46\u00a0mm) at 14 to 15\u00a0weeks to 15.9\u00a0mm (+\/\u22121.7\u00a0mm) at 29 to 35\u00a0weeks. We found high intraobserver and interobserver correlation between measurements. All four cases diagnosed by this approach were confirmed postnatally.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The SHPI, representing the normally developed secondary bony palate, can be imaged in the fetus by direct 2D ultrasound as early as 14\u00a0weeks. A gap within or nonvisualization of the SHPI is highly suggestive for a secondary palate cleft.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5385","type":"journal-article","created":{"date-parts":[[2018,11,7]],"date-time":"2018-11-07T09:10:24Z","timestamp":1541581824000},"page":"1049-1054","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Ultrasound imaging of the fetal secondary palate: Methodological description of a two\u2010dimensional approach and a case series"],"prefix":"10.1002","volume":"38","author":[{"given":"Michael","family":"Brusilov","sequence":"first","affiliation":[{"name":"OB\u2010GYN Ultrasound Unit Lis Maternity Hospital, Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igal","family":"Wolman","sequence":"additional","affiliation":[{"name":"OB\u2010GYN Ultrasound Unit Lis Maternity Hospital, Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eran","family":"Ashwal","sequence":"additional","affiliation":[{"name":"OB\u2010GYN Ultrasound Unit Lis Maternity Hospital, Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Malinger","sequence":"additional","affiliation":[{"name":"OB\u2010GYN Ultrasound Unit Lis Maternity Hospital, Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1073-6348","authenticated-orcid":false,"given":"Roee","family":"Birnbaum","sequence":"additional","affiliation":[{"name":"OB\u2010GYN Ultrasound Unit Lis Maternity Hospital, Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1597\/09-217"},{"key":"e_1_2_7_3_1","volume-title":"Human Genetics Programme, World Health Organization. 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