{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T19:42:26Z","timestamp":1788810146696,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T00:00:00Z","timestamp":1545350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100013395","name":"National System of Researchers","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013395","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Mexican National Council for Science and Technology (CONACyT), Mexico"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objectives of the study are to evaluate longitudinal changes in lung size and intrapulmonary\u2010artery (IPa) Doppler in fetuses with congenital diaphragmatic hernia (CDH) and assess their contribution in predicting neonatal survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The observed\/expected lung\u2010to\u2010head ratio (O\/E\u2010LHR) and IPa\u2013pulsatility index (PI) and peak early diastolic reversed flow (PEDRF) were evaluated in a cohort of left\u2010sided CDH fetuses managed expectantly during pregnancy. Longitudinal changes were analyzed by multilevel analysis, and their value to predict survival using the multiple logistic regression and decision\u2010tree analysis was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 232 scans were performed on 69 CDH fetuses. The O\/E\u2010LHR values remained unchanged during fetal monitoring, whereas IPa\u2013PI and PEDRF showed a progressive increase throughout follow\u2010up, becoming abnormal on average at 30\u00a0weeks of gestation. Absent\/reversed end\u2010diastolic velocity (EDV) in the IPa was observed in 20.3%. O\/E\u2010LHR and IPa Doppler indices were significantly associated with probability of survival (O\/E\u2010LHR\u00a0\u2265\u00a026%, odds ratio [OR] 19.0; IPa\u2013PI &lt;+2.0 <jats:italic>z<\/jats:italic> score, OR 3.0; and positive EDV, OR 7.4). All cases with IPa\u2010reversed EDV died after birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>While lung size remains stable during pregnancy, CDH fetuses show progressive deterioration in intrapulmonary blood flow. IPa Doppler evaluation may aid in predicting survival of CDH fetuses managed expectantly during pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5401","type":"journal-article","created":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T13:14:37Z","timestamp":1543929277000},"page":"45-51","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Longitudinal changes in lung size and intrapulmonary\u2010artery Doppler during the second half of pregnancy in fetuses with congenital diaphragmatic hernia"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5999-866X","authenticated-orcid":false,"given":"Rogelio","family":"Cruz\u2010Martinez","sequence":"first","affiliation":[{"name":"Department of Fetal Surgery, Children and Women's Specialty Hospital of Queretaro Queretaro, Mexico Fetal Medicine Mexico Foundation  Queretaro Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Mart\u00ednez\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Fetal Surgery, Children and Women's Specialty Hospital of Queretaro Queretaro, Mexico Fetal Medicine Mexico Foundation  Queretaro Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"Nieto\u2010Castro","sequence":"additional","affiliation":[{"name":"Department of Fetal Surgery, Children and Women's Specialty Hospital of Queretaro Queretaro, Mexico Fetal Medicine Mexico Foundation  Queretaro Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alma","family":"G\u00e1mez\u2010Varela","sequence":"additional","affiliation":[{"name":"Department of Fetal Surgery, Children and Women's Specialty Hospital of Queretaro Queretaro, Mexico Fetal Medicine Mexico Foundation  Queretaro Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6807-3578","authenticated-orcid":false,"given":"Monica","family":"Cruz\u2010Lemini","sequence":"additional","affiliation":[{"name":"Department of Fetal Surgery, Children and Women's Specialty Hospital of Queretaro Queretaro, Mexico Fetal Medicine Mexico Foundation  Queretaro Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonahtan","family":"Luna\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Fetal Surgery, Children and Women's Specialty Hospital of Queretaro Queretaro, Mexico Fetal Medicine Mexico Foundation  Queretaro Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel","family":"Ju\u00e1rez\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Fetal Surgery, Children and Women's Specialty Hospital of Queretaro Queretaro, Mexico Fetal Medicine Mexico Foundation  Queretaro Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)30206-9"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00252.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2004.03.049"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3863"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00132584-200110000-00004"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.3.532"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-006-0300-3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.156158"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5167"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(98)00327-3"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.69"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5201"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7753"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000320249"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.05.010"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.9177"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11212"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7593"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13420"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(96)90338-3"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4052"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(01)00368-2"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199706000-00016"},{"key":"e_1_2_8_25_1","volume-title":"Multilevel Statistical Models","author":"Goldstein H","year":"1995"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6144"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.04.004"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.44"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12414"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-010-1579-9"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(97)90181-0"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000254485"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7592"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000441026"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00134.x"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.5401","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.5401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T12:23:45Z","timestamp":1694694225000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.5401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,21]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1002\/pd.5401"],"URL":"https:\/\/doi.org\/10.1002\/pd.5401","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,21]]},"assertion":[{"value":"2018-03-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}