{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T01:43:01Z","timestamp":1786239781384,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T00:00:00Z","timestamp":1547078400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the reasons for nonreportable cell\u2010free DNA (cfDNA) results in noninvasive prenatal testing (NIPT), we retrospectively studied maternal characteristics and other details associated with the results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicenter retrospective cohort study in pregnant women undergoing NIPT by massively parallel sequencing (MPS) with failed cfDNA tests was performed between April 2013 and March 2017. The women's data and MPS results were analyzed in terms of maternal characteristics, test performance, fetal fraction (FF), <jats:italic>z<\/jats:italic> scores, anticoagulation therapy, and other details of the nonreportable cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 110 (0.32%) of 34\u00a0626 pregnant women had nonreportable cfDNA test results after an initial blood sampling; 22 (20.0%) cases had a low FF (&lt;4%), and 18 (16.4%) cases including those with a maternal malignancy, were found to have altered genomic profile. Approximately half of the cases with nonreportable results had borderline <jats:italic>z<\/jats:italic> score. Among the women with nonreportable results because of altered genomic profile, the success rate of retesting using a second blood sampling was relatively low (25.0%\u201033.3%). Thirteen (11.8%) of the women with nonreportable results had required hypodermic heparin injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The classification of nonreportable results using cfDNA analysis is important to provide women with precise information and to reduce anxiety during pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5408","type":"journal-article","created":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T15:08:14Z","timestamp":1545836894000},"page":"100-106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Classification of factors involved in nonreportable results of noninvasive prenatal testing (NIPT) and prediction of success rate of second NIPT"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9003-1289","authenticated-orcid":false,"given":"Nobuhiro","family":"Suzumori","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"},{"name":"Division of Clinical and Molecular Genetics Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Sekizawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Showa University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"},{"name":"Division of Clinical and Molecular Genetics Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Samura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiko","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Division of Fetal Medicine Center for Maternal\u2010Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina","family":"Akaishi","sequence":"additional","affiliation":[{"name":"Division of Fetal Medicine Center for Maternal\u2010Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development  Tokyo 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