{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T23:50:48Z","timestamp":1773186648738,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T00:00:00Z","timestamp":1552867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Prenatal occurrence and timing of appearance of associated features in Beckwith\u2010Wiedemann syndrome (BWS) are unknown. We reviewed our BWS patients with serial fetal imaging and correlated these with postnatal findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All BWS patients with fetal ultrasound (US) or magnetic resonance imaging (MRI) from 2000 to 2016 were reviewed to determine the presence of polyhydramnios, placentamegaly, macrosomia, macroglossia, retrognathia, omphalocele, visceromegaly, and hemihypertrophy. These observations were correlated with postnatal findings. Data were analyzed by Mann\u2013Whitney U test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine BWS patients underwent 42 fetal imaging studies with median of five (range of two to six) studies per patient between 13 and 35\u00a0weeks gestation. All prenatal findings were confirmed postnatally with complete concordance. All patients with omphalocele were detected early in gestation but other postnatal findings less predictably so. All omphaloceles were small, and were found significantly earlier in gestation than macrosomia (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.004) and macroglossia (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.012). Visceromegaly and retrognathia were less frequent, with no significant differences in median gestational age from omphalocele when prenatally identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In BWS, omphalocele is the most common prenatal finding and routinely observed in early gestation with 100% accuracy. Associated findings of macrosomia, macroglossia, visceromegaly, and retrognathia, when present, are detected later in gestation. Imaging in later gestation may reveal additional abnormalities that support a BWS diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5440","type":"journal-article","created":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T07:52:38Z","timestamp":1550649158000},"page":"792-795","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Prenatal imaging throughout gestation in Beckwith\u2010Wiedemann syndrome"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9438-1654","authenticated-orcid":false,"given":"Hester F.","family":"Shieh","sequence":"first","affiliation":[{"name":"Department of Surgery Boston Children's Hospital, Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judy A.","family":"Estroff","sequence":"additional","affiliation":[{"name":"Advanced Fetal Care Center Boston Children's Hospital, Harvard Medical School  Boston MA USA"},{"name":"Department of Radiology Boston Children's Hospital, Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol E.","family":"Barnewolt","sequence":"additional","affiliation":[{"name":"Advanced Fetal Care Center Boston Children's Hospital, Harvard Medical School  Boston MA USA"},{"name":"Department of Radiology Boston Children's Hospital, Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Zurakowski","sequence":"additional","affiliation":[{"name":"Department of Surgery Boston Children's Hospital, Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Hann","family":"Tan","sequence":"additional","affiliation":[{"name":"Advanced Fetal Care Center Boston Children's Hospital, Harvard Medical School  Boston MA USA"},{"name":"Division of Genetics and Genomics Boston Children's Hospital, Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry L.","family":"Buchmiller","sequence":"additional","affiliation":[{"name":"Department of Surgery Boston Children's Hospital, Harvard Medical School  Boston MA USA"},{"name":"Advanced Fetal Care Center Boston Children's Hospital, Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,18]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"BeckwithJB.Extreme cytomegaly of the adrenal fetal cortex hyperplasia of the kidneys and pancreas and Leydig\u2010cell hyperplasia: another syndrome?Annual Meeting of Western Society for Pediatric Research Los Angeles CA November1963."},{"key":"e_1_2_8_3_1","first-page":"223","article-title":"Familial malformation complex with umbilical hernia and macroglossia\u2010a \u201cnew syndrome?\u201d","volume":"13","author":"Wiedemann HR","year":"1964","journal-title":"J 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