{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:21:38Z","timestamp":1787509298193,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T00:00:00Z","timestamp":1559520000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Cardiac remodeling due to renal dysfunction may have an impact on myocardial function (MF) of fetuses with lower urinary tract obstruction (LUTO). The aim was to identify possible differences in MF in LUTO fetuses compared with healthy controls and to look for interactions between urine biochemistry and MF indices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a cohort study consisting of 31 LUTO fetuses and 45 healthy controls. Subgroups were generated according to intrauterine therapy (group 1: LUTO after therapy, group 2: LUTO without therapy at the time of examination, and group 3: controls). MF indices were measured using pulsed wave tissue Doppler imaging and M\u2010mode. Furthermore, results of fetal urine biochemistry were gathered retrospectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among other findings, right ventricular (RV) e\u2019\/a\u2019 ratio was lower in group 1 compared with group 3 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.050). According to gestational age (GA) level\u2010dependent analysis, RV isovolumetric relaxation time was significantly longer in group 2 compared with group 1 and group 3 at GA level 1 (19\u00a0wk of gestation). A significant positive correlation between RV e\u2019\/a\u2019 ratio and \u03b2\u20102\u2010microglobulin as well as \u03b1\u20101\u2010microglobulin and potassium could be observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We observed differences in MF and an association between ventricular filling pattern and renal protein secretion in LUTO fetuses. This can be interpreted as a sign of intrauterine cardiac remodeling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.5453","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T03:40:00Z","timestamp":1554694800000},"page":"495-504","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Myocardial function in fetuses with lower urinary tract obstruction: Is there a cardiac remodeling effect due to renal damage?"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3732-7464","authenticated-orcid":false,"given":"Oliver","family":"Graupner","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital rechts der Isar Technical University of Munich  Munich 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