{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T01:29:55Z","timestamp":1778030995046,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Placenta\u2010related biological samples are used in biomedical research to investigate placental development. Metabolomics represents a promising approach for studying placental metabolism in an effort to explain physiological and pathological mechanisms. The aim of this study was to investigate metabolic changes in chorionic villi during the first trimester of pregnancy in euploid and aneuploid cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Samples from 21 women (13 euploid and eight aneuploid) were analyzed with <jats:sup>1<\/jats:sup>H\u2010nuclear magnetic resonance (NMR), gas chromatography\u2013mass spectrometry (GC\u2010MS), and high\u2010performance liquid chromatography (HPLC). Multivariate statistical analysis was performed, and differences in metabolites were used to identify the altered metabolic pathways.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A regression model to test the correlation between fetal crown\u2010rump length (CRL) and metabolic profile of chorionic villi was performed in euploid pregnancies (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> was 0.69 for the NMR analysis and 0.94 for the GC\u2010MS analysis). Supervised analysis was used to compare chorionic villi of euploid and aneuploid fetuses (NMR: <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup><jats:italic>X<\/jats:italic>\u00a0=\u00a00.70, <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup><jats:italic>Y<\/jats:italic>\u00a0=\u00a00.65, <jats:italic>Q<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.30, <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup><jats:italic>X<\/jats:italic>\u00a0=\u00a00.62; GC\u2010MS: <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup><jats:italic>Y<\/jats:italic>\u00a0=\u00a00.704, <jats:italic>Q<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.444). Polyol pathways, myo\u2010inositol, and oxidative stress seem to have a fundamental role in euploid and aneuploid pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Polyol pathways may have a crucial role in energy production in early pregnancy. Excessive activation in aneuploid pregnancies may lead to increased oxidative stress. Metabolomics represents a promising approach to investigate placental metabolic changes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5461","type":"journal-article","created":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T19:58:48Z","timestamp":1555531128000},"page":"848-858","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Metabolic fingerprinting of chorionic villous samples in normal pregnancy and chromosomal disorders"],"prefix":"10.1002","volume":"39","author":[{"given":"Federica","family":"Murgia","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Clinical Metabolomics Unit University of Cagliari  Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7260-1660","authenticated-orcid":false,"given":"Ambra","family":"Iuculano","sequence":"additional","affiliation":[{"name":"Department of Prenatal and Preimplantation Genetic Diagnosis and Fetal Therapy Ospedale Pediatrico Microcitemico A. 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Cao  Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Laura","family":"Santoru","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Clinical Metabolomics Unit University of Cagliari  Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Tronci","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Clinical Metabolomics Unit University of Cagliari  Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Deiana","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Clinical Metabolomics Unit University of Cagliari  Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Atzori","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Clinical Metabolomics Unit University of Cagliari  Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Monni","sequence":"additional","affiliation":[{"name":"Department of Prenatal and Preimplantation Genetic Diagnosis and Fetal Therapy Ospedale Pediatrico Microcitemico A. 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