{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T08:04:49Z","timestamp":1763366689492},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,1,30]],"date-time":"2003-01-30T00:00:00Z","timestamp":1043884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study PAPP\u2010A and SP1 for biochemical trisomy screening in twin pregnancies and to investigate the role of maternal and placental compartments in marker production by comparing the levels of the decidual cytokine M\u2010CSF with the PAPP\u2010A and SP1 from the placenta.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirteen twin pregnancies with at least one chromosomally abnormal fetus were compared with 68 normal twin pregnancies. Sera were obtained between 11 + 3 and 13 + 6 weeks of gestation, and PAPP\u2010A, SP1 and M\u2010CSF levels were determined by immunoassay. These concentrations were also compared with gestation\u2010matched groups of 18 singleton normal pregnancies and 18 singleton Down syndrome pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PAPP\u2010A and SP1, but not M\u2010CSF, levels were higher in normal twin pregnancy than in normal singleton pregnancy. SP1 levels, but not PAPP\u2010A, correlated to M\u2010CSF. PAPP\u2010A, but not SP1, levels were reduced in abnormal twin pregnancies, with an increasing effect according to the number of affected fetuses, and were more pronounced in pregnancies with trisomy 18 or 13 than in trisomy 21 fetuses. M\u2010CSF was inconsistent, with a trend towards increased levels in trisomy 21.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PAPP\u2010A remains the best biochemical screening marker for fetal trisomies 21, 18 or 13, in singleton as well as in twin pregnancy. In contrast to SP1, its site of production is not likely to be restricted to the placenta. The role of the (maternally produced) M\u2010CSF remains to be further investigated. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.547","type":"journal-article","created":{"date-parts":[[2003,2,7]],"date-time":"2003-02-07T07:10:26Z","timestamp":1044601826000},"page":"157-162","source":"Crossref","is-referenced-by-count":17,"title":["First\u2010trimester maternal serum PAPP\u2010A, SP1 and M\u2010CSF levels in normal and trisomic twin pregnancies"],"prefix":"10.1002","volume":"23","author":[{"given":"N. A.","family":"Bersinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Noble","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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