{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T20:09:27Z","timestamp":1762459767395,"version":"3.40.5"},"reference-count":11,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,28]],"date-time":"2019-07-28T00:00:00Z","timestamp":1564272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess whether levels of first\u2010trimester pregnancy\u2010associated plasma protein A (PAPP\u2010A) differ between women with and without sickle cell disease (SCD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective study of 101 singleton pregnancies in women with SCD (including 55 with genotype HbSS, 37 with genotype HbSC, and nine with other genotypes). Measured levels of PAPP\u2010A were converted to multiple of the median (MoM) values corrected for gestational age and maternal characteristics. Median PAPP\u2010A MoM in the SCD group was compared with that of 1010 controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the SCD group median, PAPP\u2010A MoM was lower than in the non\u2010SCD group (0.72, interquartile range [IQR] = 0.54\u20101.14 versus 1.09, IQR = 0.74\u20101.49; <jats:italic>P<\/jats:italic> &lt; .001). Within the SCD group median PAPP\u2010A MoM was lower for those with genotype HbSS than HbSC (0.62, IQR = 0.44\u20101.14 versus 0.94, IQR = 0.72\u20101.25; .006). In 7.3% (4\/55) of the HbSS group, there was stillbirth, and in these cases, PAPP\u2010A was less than or equal to 0.5 MoM; in the control group, the incidence of stillbirth was lower (1%; <jats:italic>P<\/jats:italic> &lt; .001). In HbSS disease, the incidence of small for gestational age (SGA) neonates was increased.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pregnancies with HbSS have lower PAPP\u2010A MoM values and higher incidence of stillbirth and birth of SGA neonates than in non\u2010SCD controls.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5507","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T01:44:21Z","timestamp":1561513461000},"page":"921-924","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Does first\u2010trimester serum pregnancy\u2010associated plasma protein A differ in pregnant women with sickle cell disease?"],"prefix":"10.1002","volume":"39","author":[{"given":"Gergana","family":"Peeva","sequence":"first","affiliation":[{"name":"Women's Services Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Oakley","sequence":"additional","affiliation":[{"name":"Department of Non\u2010communicable Disease Epidemiology London School of Hygiene and Tropical Medicine  London UK"},{"name":"Centre for Fertility and Health Norwegian Institute of Public Health  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inez","family":"von R\u00e8ge","sequence":"additional","affiliation":[{"name":"Women's Services Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kypros","family":"Nicolaides","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre of Fetal Medicine King's College Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8867-2909","authenticated-orcid":false,"given":"Eugene","family":"Oteng\u2010Ntim","sequence":"additional","affiliation":[{"name":"Women's Services Guy's and St Thomas' NHS Foundation Trust  London UK"},{"name":"Women's Health Academic Centre King's College London  London UK"},{"name":"Department of Non\u2010communicable Disease Epidemiology London School of Hygiene and Tropical Medicine  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2011.10.001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61229-X"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17192-4"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-11-607317"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1975.tb00710.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5331"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19073"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2475"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5165"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-2768"},{"key":"e_1_2_10_12_1","unstructured":"MBRACE\u2010UK(2017)Perinatal 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