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Identifying FGR, through its commonly used surrogate\u2014the small\u2010for\u2010gestational\u2010age (SGA, estimated fetal weight and\/or abdominal circumference &lt;10th centile) fetus\u2014and instituting fetal surveillance and timely delivery decrease stillbirth risk. Methods available to clinicians for antenatal identification of SGA fetuses have surprisingly poor sensitivity. About 80% of cases remain undetected. Measuring the symphysis\u2010fundal height detects only 20% of SGA fetuses, and even universal third trimester ultrasound detects, at best, 57% of those born SGA. There is an urgent need to find better ways to identify this at\u2010risk cohort. This review summarises efforts to identify molecular biomarkers (proteins, metabolites, or ribonucleic acids) that could be used to better predict FGR. Most studies examining potential biomarkers to date have utilised case\u2010control study designs without proceeding to validation in independent cohorts. To develop a robust test for FGR, large prospective studies are required with a priori validation plans and cohorts. Given that current clinical care detects 20% of SGA fetuses, even a screening test with \u226560% sensitivity at 90% specificity could be clinically useful, if developed. This may be an achievable aspiration. If discovered, such a test may decrease stillbirth.<\/jats:p>","DOI":"10.1002\/pd.5525","type":"journal-article","created":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T19:39:16Z","timestamp":1562960356000},"page":"947-957","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Blood\u2010based biomarkers in the maternal circulation associated with fetal growth restriction"],"prefix":"10.1002","volume":"39","author":[{"given":"Stephen","family":"Tong","sequence":"first","affiliation":[{"name":"Mercy Perinatal Mercy Hospital for Women  Melbourne Victoria Australia"},{"name":"Translational Obstetrics Group, Department of Obstetrics and Gynaecology University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6233-9737","authenticated-orcid":false,"given":"Tu'uhevaha","family":"Joy Kaitu'u\u2010Lino","sequence":"additional","affiliation":[{"name":"Mercy Perinatal Mercy Hospital for Women  Melbourne Victoria Australia"},{"name":"Translational Obstetrics Group, Department of Obstetrics and Gynaecology University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan Philippa","family":"Walker","sequence":"additional","affiliation":[{"name":"Mercy Perinatal Mercy Hospital for Women  Melbourne Victoria Australia"},{"name":"Translational Obstetrics Group, Department of Obstetrics and Gynaecology University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9099-7745","authenticated-orcid":false,"given":"Teresa Mary","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Mercy Perinatal Mercy Hospital for Women  Melbourne Victoria Australia"},{"name":"Translational Obstetrics Group, Department of Obstetrics and Gynaecology University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62233-7"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f108"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16809-8"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62049-3"},{"issue":"6","key":"e_1_2_10_6_1","first-page":"CD007529","article-title":"Fetal and umbilical Doppler ultrasound in high\u2010risk pregnancies","volume":"13","author":"Alfirevic Z","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2007.00742.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000388"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c7087"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60736-4"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1509117"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1800566"},{"key":"e_1_2_10_13_1","unstructured":"The Royal College of Obstetricians and Gynaecologists.The investigation and management of the small\u2010for\u2010gestational\u2010age fetus. 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