{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T02:53:15Z","timestamp":1768272795579,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T00:00:00Z","timestamp":1565654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The purpose of the study is to examine MRI findings of the brain and spine on prenatal and postnatal MRI following intrauterine repair of open spinal dysraphism (OSD) by open hysterotomy and fetoscopic approaches.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>This study is a single\u2010center HIPAA\u2010compliant and IRB\u2010approved retrospective analysis of fetal MRIs with open spinal dysraphism from January 2011 through December 2018 that underwent subsequent prenatal repair of OSD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010two patients met inclusion criteria: 47 underwent open repair, and 15 underwent fetoscopic repair, with an average gestational age of 22.6 \u00b1 1.4 weeks at initial MRI. On postnatal MRI, spinal cord syrinx was seen in 34% (16\/47) of patients undergoing open versus 33.3% (5\/15) undergoing fetoscopic repair (<jats:italic>P<\/jats:italic> = 0.96). Postnatally, there was no significant difference in hindbrain herniation between the open versus fetoscopic repair groups (<jats:italic>P<\/jats:italic> = 0.28). Lateral ventricular size was significantly larger in the open (20.9 \u00b1 6.7 mm) versus the fetoscopic repair (16.1 \u00b1 4.9 mm) group (<jats:italic>P<\/jats:italic> = 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Though lateral ventricular size in the open repair group was larger than the fetoscopic repair group, this can likely be explained by initial selection criteria used for fetoscopic repair. Other postoperative imaging parameters on postnatal MRI were not significantly different between the two groups.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5540","type":"journal-article","created":{"date-parts":[[2019,7,27]],"date-time":"2019-07-27T18:43:01Z","timestamp":1564252981000},"page":"49-57","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Prenatal and postnatal MRI findings in open spinal dysraphism following intrauterine repair via open versus fetoscopic surgical techniques"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8251-7481","authenticated-orcid":false,"given":"Usha D.","family":"Nagaraj","sequence":"first","affiliation":[{"name":"Department of Radiology and Medical Imaging Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"},{"name":"University of Cincinnati College of Medicine  Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin S.","family":"Bierbrauer","sequence":"additional","affiliation":[{"name":"University of Cincinnati College of Medicine  Cincinnati OH USA"},{"name":"Division of Pediatric Neurosurgery Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles B.","family":"Stevenson","sequence":"additional","affiliation":[{"name":"University of Cincinnati College of Medicine  Cincinnati OH USA"},{"name":"Division of Pediatric Neurosurgery Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose L.","family":"Peiro","sequence":"additional","affiliation":[{"name":"University of Cincinnati College of Medicine  Cincinnati OH USA"},{"name":"Department of Pediatric Surgery Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Foong Yen","family":"Lim","sequence":"additional","affiliation":[{"name":"University of Cincinnati College of Medicine  Cincinnati OH USA"},{"name":"Department of Pediatric Surgery Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mounira A.","family":"Habli","sequence":"additional","affiliation":[{"name":"University of Cincinnati College of Medicine  Cincinnati OH USA"},{"name":"Department of Maternal\u2010Fetal Medicine Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3872-9027","authenticated-orcid":false,"given":"Beth M.","family":"Kline\u2010Fath","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"},{"name":"University of Cincinnati College of Medicine  Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,13]]},"reference":[{"issue":"720","key":"e_1_2_8_2_1","first-page":"164","article-title":"Committee on Obstetric Practice Society for Maternal\u2010Fetal Medicine","volume":"130","year":"2017","journal-title":"Maternal\u2010Fetal Surgery for Myelomeningocele."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2007.07.004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014379"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2011.11.021"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3171\/2015.7.PEDS15336"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.12.001"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5116"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70167-5"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000089301"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000479505"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20308"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.19.1826"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-007-0452-0"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5930"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5760"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20220"},{"key":"e_1_2_8_18_1","article-title":"Comparison of brain microstructure after prenatal spina bifida repair by either laparotomy assisted fetoscopic or open approach","author":"Cortes MS","year":"2019","journal-title":"Ultrasound Obstet Gynecol"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.11.6745"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.18.20088"},{"issue":"3","key":"e_1_2_8_21_1","first-page":"731","article-title":"Ventricles: of the fetal lateral study of normal atrial size and choroid plexus volume","volume":"164","author":"Hilpert P","year":"1995","journal-title":"atria fetal lateral Vent a Sonogr study Norm Atr size choroid Plex Vol"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-003-2027-0"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199209000-00010"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e318237a6c1"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841850510021715"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.150.1.163"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4585"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1781"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2273020535"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.181.2.1924805"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20140496"},{"issue":"2","key":"e_1_2_8_32_1","first-page":"247","article-title":"Ultrasound screening for spina bifida: cranial and cerebellar signs in a high\u2010risk population","volume":"70","author":"Campbell J","year":"1987","journal-title":"Obstet Gynecol."},{"issue":"1","key":"e_1_2_8_33_1","first-page":"54","article-title":"Early diagnosis of spina bifida: the value of cranial ultrasound markers","volume":"76","author":"Thiagarajah S","year":"1990","journal-title":"Obstet Gynecol."},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.137.1.83"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-017-4807-y"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-009-1459-3"},{"issue":"4","key":"e_1_2_8_37_1","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1542\/peds.75.4.714","article-title":"Subependymal germinal matrix hemorrhage in full\u2010term neonates","volume":"75","author":"Hayden CK","year":"1985","journal-title":"Pediatrics."}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.5540","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.5540","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pd.5540","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.5540","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T20:14:40Z","timestamp":1693944880000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.5540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,13]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1002\/pd.5540"],"URL":"https:\/\/doi.org\/10.1002\/pd.5540","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,13]]},"assertion":[{"value":"2019-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}