{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T19:13:45Z","timestamp":1777576425739,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T00:00:00Z","timestamp":1567641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"publisher","award":["Z161100004916102"],"award-info":[{"award-number":["Z161100004916102"]}],"id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701704"],"award-info":[{"award-number":["81701704"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To quantitatively assess prenatal diagnostic performance of three\u2010dimensional ultrasound (3D\u2010US) for posterior fossa anomalies (PFA) and establish a preliminarily 3D\u2010US prediction model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty singleton fetuses suspected of PFA by 2D\u2010US presented their detailed 3D\u2010US evaluation. The surface area of vermis (SAV), brainstem\u2010vermis, and brainstem\u2010tentorium angles were measured by 3D\u2010US. The good prognosis was defined as normal neurodevelopmental outcome. MRI and autopsy were the diagnostic reference standard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant difference between 2D\u2010US (60.0%, 36\/60) and 3D\u2010US (94.8%, 55\/58) for the diagnostic accuracy (<jats:italic>P<\/jats:italic> &lt; .01). Prenatal 3D\u2010US prediction model was established with observed\/expected SAV as the main predictor (area under the curve [AUC]: 0.901; 95% CI, 0.810\u20100.992, <jats:italic>P<\/jats:italic> &lt; .001). When it was more than 107.5%, the prognosis seemed to be good (sensitivity: 96.4%, specificity: 26.7%), which led to consideration of mega cisterna magna, Blake pouch cyst, or small arachnoid cyst. The prognosis appeared to be poor when it was less than 73% (sensitivity: 71.4%, specificity: 100%), and the diagnosis tended to be a Dandy\u2010Walker malformation, vermian hypoplasia, and cerebellar hypoplasia. Brainstem\u2013vermis and brainstem\u2013tentorium angles were the secondary indicators (AUC: 0.689 vs 0.761; 95% CI, 0.541\u20100.836 vs 0.624\u20100.897, <jats:italic>P<\/jats:italic> = .014 vs.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It seems that the exact types of PFA can be effectively diagnosed by quantitative indicators of 3D\u2010US.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5549","type":"journal-article","created":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T02:25:31Z","timestamp":1566527131000},"page":"1086-1095","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Quantitative diagnostic advantages of three\u2010dimensional ultrasound volume imaging for fetal posterior fossa anomalies: Preliminary establishment of a prediction model"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5387-8085","authenticated-orcid":false,"given":"Lijuan","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Ultrasound Beijing Obstetrics and Gynecology Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuixia","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Beijing Obstetrics and Gynecology Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Beijing Obstetrics and Gynecology Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiejuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Beijing Obstetrics and Gynecology Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Beijing Obstetrics and Gynecology Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Beijing Obstetrics and Gynecology Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1698-5783","authenticated-orcid":false,"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Beijing Obstetrics and Gynecology Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Obstetrics and Gynecology Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longxia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound the General Hospital of the People's Liberation Army  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingqing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Beijing Obstetrics and Gynecology Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-26398-5_4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-004-1316-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp247"},{"key":"e_1_2_9_5_1","first-page":"83","article-title":"The cisterna magna septa: vestigial remnants of Blake's pouch and a potential new marker for normal development of the rhombencephalon. 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