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The outcomes observed were: chromosomal anomalies, cystic fibrosis (CF), associated structural anomalies detected only at follow\u2010up scans and at birth, regression during pregnancy, congenital infections, intra\u2010uterine (IUD), neonatal (NND) and perinatal (PND) death. Twenty\u2010five studies (12\u2009971 fetuses) were included. Chromosomal anomalies occurred in 3.3% of the fetuses, mainly Trisomy 21 and aneuploidies involving the sex chromosomes. Cystic fibrosis occurred in 2.2%. Congenital infections affected 2.2%, mainly congenital Cytomegalovirus (CMV) infection. The majority of fetuses with EB experienced regression or disappearance of the EB at follow\u2010up scans. Associated anomalies were detected at a follow\u2010up scan in 1.8%. Associated anomalies were detected at birth and missed at ultrasound in 2.1% of cases. IUD occurred in 3.2% of cases while the corresponding figures for NND and PND were 0.4% and 3.1%. Fetuses with EB are at increased risk of adverse perinatal outcome, highlighting the need for a thorough antenatal management and postnatal follow\u2010up. Assessment during pregnancy and after birth should be performed in order to look for signs of fetal aneuploidy, congenital infections and associated structural anomalies.<\/jats:p>","DOI":"10.1002\/pd.5638","type":"journal-article","created":{"date-parts":[[2020,1,25]],"date-time":"2020-01-25T10:29:12Z","timestamp":1579948152000},"page":"391-399","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Outcome of fetal echogenic bowel: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"41","author":[{"given":"Alice","family":"D'Amico","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Chieti Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Buca","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Chieti Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Division of Maternal and Fetal Medicine, Ospedale Cristo Re University of Rome Tor Vergata Rome Italy"},{"name":"Department of Obstetrics and Gynecology I.M. 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