{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T02:02:29Z","timestamp":1778896949934,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T00:00:00Z","timestamp":1591747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2017SK50802"],"award-info":[{"award-number":["2017SK50802"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2019JJ80104"],"award-info":[{"award-number":["2019JJ80104"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to analyse the characteristics of the prenatal diagnosis (PD) of birth defects (BDs) and termination of pregnancy (TOP) for fetal anomalies and to suggest perinatal management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>BD surveillance data were collected from 52 registered hospitals in Hunan between 2015 and 2018. The PD and TOP rates of BDs were calculated to examine the associations between infant sex, maternal age, and region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 2015 to 2018, a total of 18\u2009931 fetuses with BDs were identified, of which 10\u2009299 fetuses (54.4%) were diagnosed prenatally and 9343 pregnancies (90.7% among PDs and 49.3% among BDs) were terminated. The mean gestational age at diagnosis for fetuses with BDs was 25.1\u2009\u00b1\u20095.9\u2009weeks and showed a downward trend over the study period. The average PD rate of the BDs was higher in rural areas than in urban areas (58.1% vs 50.3%), higher for female than male fetuses (57.25% vs 48.92%), and higher for mothers older than age 35 than for those younger (58.62% vs 53.69%). The average TOP rate of fetuses with BDs in rural areas was higher than that in urban areas (91.99% vs 89.12%) and decreased with increasing maternal age (<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/pd5648-math-0001.png\" xlink:title=\"urn:x-wiley:01973851:media:pd5648:pd5648-math-0001\"\/> = 7.926, <jats:italic>P<\/jats:italic> = .005). The five BDs with the highest PD rates were conjoined twins (100%), anencephaly (97.87%), congenital hydrocephalus (97.66%), chromosomal malformation (96.07%), and encephalocele (95.54%). The five BDs with the highest TOP rates among the PDs were conjoined twins (100%), exstrophy of the urinary bladder (100%), chromosomal malformation (98.09%), encephalocele (98%), and anencephaly (97.28%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>More than half of BDs were diagnosed prenatally, with the majority diagnosed at less than 28 gestational weeks. The TOP rates following PD in Hunan Province were high, especially for rural and younger mothers. The findings suggest a need for high\u2010quality, targeted counselling following PD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5648","type":"journal-article","created":{"date-parts":[[2020,1,19]],"date-time":"2020-01-19T04:47:30Z","timestamp":1579409250000},"page":"925-930","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Prenatal diagnosis of birth defects and termination of pregnancy in Hunan Province, China"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6901-7044","authenticated-orcid":false,"given":"Donghua","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Information Management Maternal and Child Health Hospital of Hunan Province  Changsha Hunan China"},{"name":"NHC Key Laboratory of Birth Defect for Research and Prevention Hunan Provincial Maternal and Child Health Care Hospital  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changbiao","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Health Care Management Maternal and Children Hospital of Hunan Province  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueyun","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Maternal and Child Health Hospital of Hunan Province  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aihua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Information Management Maternal and Child Health Hospital of Hunan Province  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Information Management Maternal and Child Health Hospital of Hunan Province  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanjuan","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Information Management Maternal and Child Health Hospital of Hunan Province  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2234-6008","authenticated-orcid":false,"given":"Haoxian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shunde Hospital of Southern Medical University  Foshan City Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Information Management Maternal and Child Health Hospital of Hunan Province  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Wang","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Birth Defect for Research and Prevention Hunan Provincial Maternal and Child Health Care Hospital  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.01700.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5023"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5117"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1651"},{"key":"e_1_2_11_6_1","unstructured":"China N H C O. Measures for the use of prenatal diagnosis technology[Z]. 2002:2019http:\/\/www.nhc.gov.cn\/wjw\/bmgz\/200804\/1787a65fde4c404ca60c341ab1fd6381.shtml."},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050802483106"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.206623"},{"issue":"03","key":"e_1_2_11_9_1","first-page":"588","article-title":"The analysis of 860 congenital heart disease cases in Beijing, China","volume":"33","author":"Li Y","year":"2018","journal-title":"Women and Children health of China"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4516"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-028139"},{"key":"e_1_2_11_12_1","unstructured":"Province P G O H. 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