{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T15:40:53Z","timestamp":1793374853370,"version":"4.5.0"},"reference-count":99,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK089201"],"award-info":[{"award-number":["R01DK089201"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD091731"],"award-info":[{"award-number":["R01HD091731"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD075858"],"award-info":[{"award-number":["HD075858"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Despite decades of messages warning about the dangers of tobacco use in pregnancy, 10% to 15% of pregnant women continue to smoke. Furthermore, an increased popularity of electronic nicotine delivery systems (ENDS) over the past decade in women of childbearing age raises parallel concerns regarding the effects of vaporized nicotine use in pregnancy. While research using animal models which mimic tobacco smoke and nicotine exposure in pregnancy have largely replicated findings in humans, few studies focus directly on the effects of these exposures on the placenta. Because the placenta is a fetal derived tissue, and nicotine and other components of tobacco smoke are either processed by or transported directly through the placenta, such studies help us understand the risks of these exposures on the developing fetus. In this review, we summarize research on the placenta and placental\u2010derived cells examining either tobacco smoke or nicotine exposure, including both histologic and subcellular (ie, epigenetic and molecular) modifications. Collectively, these studies reveal that tobacco and nicotine exposure are accompanied by some common and several unique molecular and epigenomic placental modifications. Consideration of the nature and sequelae of these molecular mediators of risk may help to better inform the public and more effectively curtail modifiable behavior.<\/jats:p>","DOI":"10.1002\/pd.5660","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T12:01:38Z","timestamp":1580731298000},"page":"1193-1200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["The impact of tobacco chemicals and nicotine on placental development"],"prefix":"10.1002","volume":"40","author":[{"given":"Melissa A.","family":"Suter","sequence":"first","affiliation":[{"name":"Baylor College of Medicine Department of Obstetrics and Gynecology  Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2960-0371","authenticated-orcid":false,"given":"Kjersti M.","family":"Aagaard","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine Department of Obstetrics and Gynecology  Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(57)90391-5"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5153.673"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2016.05.030"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6190"},{"key":"e_1_2_11_6_1","unstructured":"DimesMo. March of Dimes: PeriStats Database [Available from: marchofdimes.org\/peristats.2019"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/SAR.S84239"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/17437199.2018.1488602"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntw241"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.13802"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2196\/mhealth.3846"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-019-1204-y"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l5275"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S175970"},{"key":"e_1_2_11_15_1","unstructured":"Statement from FDA Commissioner ScottGottlieb M.D. on advancing new policies aimed at preventing youth access to and appeal of flavored tobacco products including e\u2010cigarettes and cigars [press release]. 03\/13\/20192019."},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.18332\/tid\/104724"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00071.2006"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/01902141003714023"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2012.03.006"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.05.044"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2005.77"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-005-0022-5"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00925-0"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2004.12.037"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(87)90130-4"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.11.013"},{"issue":"12","key":"e_1_2_11_27_1","first-page":"1","article-title":"Molecular cross\u2010talk at the feto\u2010maternal Interface","volume":"5","author":"Lash GE","year":"2015","journal-title":"Cold Spring Harb Perspect Med"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2011.01.005"},{"issue":"2","key":"e_1_2_11_29_1","first-page":"165","article-title":"Predictive factors for intrauterine growth restriction","volume":"7","author":"Albu AR","year":"2014","journal-title":"J Med Life."},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(89)90405-5"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.207597.116"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2018.01.001"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.07.011"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008599"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.12.041"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.01.193"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep41389"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20030712"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.101"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-16-0495"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1570027"},{"issue":"2","key":"e_1_2_11_42_1","first-page":"507","article-title":"Placenta changes in pregnancy with gestational diabetes","volume":"57","author":"Edu A","year":"2016","journal-title":"Rom J Morphol Embryol."},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13448"},{"issue":"2","key":"e_1_2_11_44_1","first-page":"138","article-title":"Placental morphology in fetal alcohol spectrum disorders","volume":"52","author":"Tai M","year":"2017","journal-title":"Alcohol Alcohol."},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.06.049"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2010.01.013"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.06.023"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.4161\/epi.6.11.17819"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.2217\/epi.12.7"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpns.14"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2017.07.010"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22506"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719111426600"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2018.04.009"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15051033"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gas050"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2009.04.010"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/761264"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-010-1338-9"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12183"},{"issue":"5","key":"e_1_2_11_61_1","first-page":"813","article-title":"Influence of maternal smoking during pregnancy on oxidant status in amniotic fluid","volume":"26","author":"Dittrich R","year":"2012","journal-title":"In Vivo."},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2011.06.022"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.4161\/epi.6.11.17819"},{"key":"e_1_2_11_64_1","first-page":"CD004072","article-title":"Vitamin C supplementation in pregnancy","volume":"9","author":"Rumbold A","year":"2015","journal-title":"Cochrane Database Syst Rev."},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300544"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2011.02.001"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200408-1029OC"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2017.05.008"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201805-1011OC"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.5217"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1237426"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-14-0334"},{"issue":"2","key":"e_1_2_11_73_1","first-page":"94","article-title":"Genetic and epigenetic influences associated with intrauterine growth restriction due to in utero tobacco exposure","volume":"8","author":"Suter M","year":"2010","journal-title":"Pediatr Endocrinol Rev."},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201610-2141OC"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.4161\/epi.5.7.12762"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-016-1113-4"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2017.09.013"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198409063111014"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1159\/000457063"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.3122\/jabfm.2017.06.170183"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-015-2586-4"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23333"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2004.10.009"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X15666170912110450"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00478.2013"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2014.02.015"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2018.02.017"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2018.1463240"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016341003692253"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122295"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2013.10.032"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfw019"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5232"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.6.2011097"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.12.042"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2010.03.014"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.18959"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2016.12.014"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2010.11.010"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2019.08.031"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.5660","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.5660","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pd.5660","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.5660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T23:38:58Z","timestamp":1693352338000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.5660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,11]]},"references-count":99,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1002\/pd.5660"],"URL":"https:\/\/doi.org\/10.1002\/pd.5660","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,11]]},"assertion":[{"value":"2019-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}