{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:24:29Z","timestamp":1792275869170,"version":"4.4.0"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T00:00:00Z","timestamp":1585612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The purpose of this study is to describe the imaging findings in a group of fetuses with suspected agenesis of the septum pellucidum (ASP) and to evaluate their clinical outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective multicenter study on a cohort of fetuses diagnosed with suspected ASP, between 2008 and 2017. The records of each patient, including ultrasound (US) and magnetic resonance studies, were reviewed and compared with the postnatal findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty\u2010seven patients were included in the study at a mean gestational age of 26.6\u2009weeks. In 17 patients, the ASP was considered isolated. Fourteen patients delivered live\u2010born, and all 14 are developing normally. Three were lost to follow\u2010up. Twenty\u2010four patients had associated malformations involving the central nervous system (CNS); 13 were delivered (normal development [5], abnormal [6] and no follow\u2010up [2]). Nine patients opted for termination, and two pregnancies were lost to follow\u2010up.<\/jats:p>\n                    <jats:p>Six patients had non\u2010CNS associated findings, two were delivered with normal neurological development and four had a termination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Isolated ASP is usually associated with a favorable outcome; but in the presence of associated malformations, there is at least a 50% risk of abnormal development. Current imaging techniques can provide an accurate prognosis in cases when ASP appears isolated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.5663","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T03:13:23Z","timestamp":1581304403000},"page":"674-680","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Agenesis of the septum pellucidum: Prenatal diagnosis and outcome"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7333-312X","authenticated-orcid":false,"given":"Tamar","family":"Borkowski\u2010Tillman","sequence":"first","affiliation":[{"name":"Division of Ultrasound in Obstetrics &amp; Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Israel and Sackler School of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4079-8152","authenticated-orcid":false,"given":"Raquel","family":"Garcia\u2010Rodriguez","sequence":"additional","affiliation":[{"name":"Prenatal Diagnosis and Fetal Therapy Unit, Obstetrics and Gynecology Service Complejo Hospitalario Universitario Insular Materno Infantil de Canarias  Las Palmas de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4272-8847","authenticated-orcid":false,"given":"Fernando","family":"Vi\u00f1als","sequence":"additional","affiliation":[{"name":"Centro AGB Ultrasonografia Clinica Sanatorio Aleman and Department Obstetrics and Gynecology Universidad de Concepcion  Concepcion Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Branco","sequence":"additional","affiliation":[{"name":"Obstetricia B \u2010 Centro Hospitalar e Universit\u00e1rio de Coimbra  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9868-3548","authenticated-orcid":false,"given":"Karina","family":"Kradjen\u2010Haratz","sequence":"additional","affiliation":[{"name":"Division of Ultrasound in Obstetrics &amp; Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Israel and Sackler School of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Fetal Neurology Clinic, Pediatric Neurology Unit, Wolfson Medical Center, Holon, and Sackler School of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liat","family":"Ben\u2010Sira","sequence":"additional","affiliation":[{"name":"Division of Pediatric Radiology, Tel Aviv Sourasky Medical Center, Israel and Sackler School of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tally","family":"Lerman\u2010Sagie","sequence":"additional","affiliation":[{"name":"Fetal Neurology Clinic, Pediatric Neurology Unit, Wolfson Medical Center, Holon, and Sackler School of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Malinger","sequence":"additional","affiliation":[{"name":"Division of Ultrasound in Obstetrics &amp; Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Israel and Sackler School of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1787"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.152.2.353"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2010.06.008"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3909"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15862"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17227"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8847"},{"key":"e_1_2_7_9_1","first-page":"476","article-title":"Ultrasound nomograms of the fetal optic nerve sheath diameter","volume":"40","author":"Haratz K","year":"2018","journal-title":"Eur J Ultrasound"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1807"},{"issue":"3","key":"e_1_2_7_11_1","first-page":"442","article-title":"Handbook of clinical neurology, vol. 30 (congenital malformations of the brain and skull, part I)","volume":"38","author":"Potter J","year":"1978","journal-title":"J Neurol Sci"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-004-1378-2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2628"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5247"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNN.0b013e3181910f02"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.1.4.385"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2018.08.029"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.5663","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pd.5663","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.5663","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T00:18:58Z","timestamp":1693959538000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.5663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,31]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1002\/pd.5663"],"URL":"https:\/\/doi.org\/10.1002\/pd.5663","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,31]]},"assertion":[{"value":"2019-11-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}