{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:04:06Z","timestamp":1782255846830,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T00:00:00Z","timestamp":1583280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the key sonographic features for the diagnosis of sirenomelia in the first trimester of pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cases of sirenomelia from several prenatal diagnosis centers were retrospectively identified and reviewed. The diagnosis was established through the detection of fused lower limbs. Additional sonographic findings were also noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 12 cases were collected. The most striking sonographic finding was the detection of malformed lower limbs, which appeared to be fused and in an atypical position. Nuchal translucency thickness was mildly increased in three cases (25%). An abdominal cyst, representing the dilated blind\u2010ending bowel, was noted in seven cases (58%). Color flow imaging detected a single umbilical artery in six cases (50%) and the associated intra\u2010abdominal vascular anomalies in three cases (25%). No cases of aneuploidy were detected. The pregnancy was terminated in nine cases (75%) and intrauterine demise occurred in the remaining three cases (25%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The sonographic detection of abnormal lower limbs or an intra\u2010abdominal cyst located laterally during the first\u2010trimester scan may be warning signs of sirenomelia. This should prompt a detailed examination of the fetal lower body and intra\u2010abdominal anatomy, including the main abdominal vessels, in order to look for additional confirmatory findings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5667","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T14:45:06Z","timestamp":1581345906000},"page":"626-634","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["First\u2010trimester sonographic diagnosis of sirenomelia: A multicenter series of 12 cases and review of the literature"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3856-574X","authenticated-orcid":false,"given":"Waldo","family":"Sepulveda","sequence":"first","affiliation":[{"name":"Fetal Imaging Unit FETALMED\u2010Maternal\u2010Fetal Diagnostic Center  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2603-8272","authenticated-orcid":false,"given":"Eran","family":"Bornstein","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Lennox Hill Hospital, Northwell Health  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Andreeva","sequence":"additional","affiliation":[{"name":"Medical\u2010Genetics Department Moscow Regions Research Institute of Obstetrics and Gynecology  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Montano","sequence":"additional","affiliation":[{"name":"Ultrasound Unit, Department of Obstetrics and Gynecology Clinica Indisa  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Ultrasound Unit, Department of Obstetrics and Gynecology Clinica Indisa  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Martinez\u2010Ten","sequence":"additional","affiliation":[{"name":"DELTA\u2014Ultrasound Diagnostic Center for Obstetrics and Gynecology  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Meagher","sequence":"additional","affiliation":[{"name":"Monash Ultrasound for Women  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,4]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"7","article-title":"Sirenomelia. 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