{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T04:58:18Z","timestamp":1785387498335,"version":"3.55.0"},"reference-count":59,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T00:00:00Z","timestamp":1583712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006506","name":"Minist\u00e9rio da Sa\u00fade","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006506","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze the impact of gestational age (GA) at the time of fetal open spinal dysraphism (OSD) repair through a mini\u2010hysterotomy on the perinatal outcomes and the infants' ventriculoperitoneal shunt rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective study of cases of fetal OSD correction performed from 2014 and 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and ninety women underwent fetal surgery for OSD through a mini\u2010hysterotomy, and 176 (176\/190:92.6%) have since delivered. Fetal OSD correction performed earlier in the gestational period, ranging from 19.7 to 26.9\u2009weeks, was associated with lower rates of postnatal ventriculoperitoneal shunting (<jats:italic>P<\/jats:italic>: .049). Earlier fetal surgeries were associated with shorter surgical times (<jats:italic>P<\/jats:italic>: .01), smaller hysterotomy lengths (<jats:italic>P<\/jats:italic> &lt;\u2009.001), higher frequencies of hindbrain herniation reversal (<jats:italic>P<\/jats:italic>: .003), and longer latencies from surgery to delivery (<jats:italic>P<\/jats:italic> &lt;\u2009.001). Median GA at delivery was 35.3\u2009weeks. Multivariate binary logistic regression showed that both fetal lateral ventricle\u2010to\u2010hemisphere ratio (%; <jats:italic>P<\/jats:italic> &lt;\u2009.001; OR: 1.14 [95% CI: 1.09\u20101.21]) and GA at the time of fetal surgery (<jats:italic>P<\/jats:italic>: .016; OR: 1.37 [95% CI: 1.07\u20101.77]) were independent predictors of postnatal ventriculoperitoneal shunting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fetuses with OSD who were operated on earlier in the gestational interval, which ranged from 19.7 to 26.9\u2009weeks, were less prone to receiving postnatal ventriculoperitoneal shunts.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5675","type":"journal-article","created":{"date-parts":[[2020,2,29]],"date-time":"2020-02-29T10:38:06Z","timestamp":1582972686000},"page":"689-697","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Fetal open spinal dysraphism repair through a mini\u2010hysterotomy: Influence of gestational age at surgery on the perinatal outcomes and postnatal shunt rates"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7279-5311","authenticated-orcid":false,"given":"Cleisson F. A.","family":"Peralta","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit HCor Hospital do Cora\u00e7\u00e3o  S\u00e3o Paulo Brazil"},{"name":"Fetal Medicine Unit Pro Matre Paulista (Maternity Hospital \u2010 Grupo Santa Joana)  S\u00e3o Paulo Brazil"},{"name":"Fetal Medicine and Surgery Center (Gestar)  S\u00e3o Paulo Brazil"},{"name":"Fetal Medicine Unit CETRUS \u2010 S\u00e3o Paulo Ultrasound Training Center  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael D.","family":"Botelho","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit HCor Hospital do Cora\u00e7\u00e3o  S\u00e3o Paulo Brazil"},{"name":"Fetal Medicine Unit Pro Matre Paulista (Maternity Hospital \u2010 Grupo Santa Joana)  S\u00e3o Paulo Brazil"},{"name":"Fetal Medicine and Surgery Center (Gestar)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edson R.","family":"Romano","sequence":"additional","affiliation":[{"name":"Intensive Care Unit HCor Hospital do Cora\u00e7\u00e3o  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Imada","sequence":"additional","affiliation":[{"name":"Department of Neuroscience HCor Hospital do Cora\u00e7\u00e3o  S\u00e3o Paulo Brazil"},{"name":"Department of Neurosurgery Pro Matre Paulista (Maternity Hospital \u2010 Grupo Santa Joana)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabr\u00edcio","family":"Lamis","sequence":"additional","affiliation":[{"name":"Department of Neuroscience HCor Hospital do Cora\u00e7\u00e3o  S\u00e3o Paulo Brazil"},{"name":"Department of Neurosurgery Pro Matre Paulista (Maternity Hospital \u2010 Grupo Santa Joana)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronaldo R.","family":"J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology HCor Hospital do Cora\u00e7\u00e3o  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Nani","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Pro Matre Paulista (Maternity Hospital \u2010 Grupo Santa Joana)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd H.","family":"Stoeber","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Pro Matre Paulista (Maternity Hospital \u2010 Grupo Santa Joana)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio A. F.","family":"de Salles","sequence":"additional","affiliation":[{"name":"Department of Neuroscience HCor Hospital do Cora\u00e7\u00e3o  S\u00e3o Paulo Brazil"},{"name":"Department of Neurosurgery Pro Matre Paulista (Maternity Hospital \u2010 Grupo Santa Joana)  S\u00e3o Paulo Brazil"},{"name":"Department of Neurosurgery University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91022-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/15513819609169297"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(97)90603-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(97)00090-X"},{"key":"e_1_2_8_6_1","first-page":"35","article-title":"The effects of amniotic fluid on the histopathologic changes of exposed spinal cord in fetal sheep","volume":"12","author":"Amouee A","year":"2009","journal-title":"Arch Iran Med"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014379"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365353"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.09.094"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3171\/2015.7.PEDS15336"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.12.001"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13430"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13389"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14937"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2013.871701"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000835"},{"key":"e_1_2_8_17_1","first-page":"214:111.e1","article-title":"Endoscopic surgery for the antenatal treatment of myelomeningocele: the CECAM trial","volume":"1","author":"Pedreira DA","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000449382"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001941"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000479683"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19001"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000479505"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19104"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15830"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443498"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20188"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)80050-6"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000028645"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70167-5"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000028735"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.19.1826"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.19.1819"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000020981"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000028849"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000028859"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65596-6"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1159\/000048010"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1159\/000067560"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1159\/000068818"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1159\/000071972"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0002-9378(03)00295-3"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1159\/000074267"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.114.2.427"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.05.054"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.01.072"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1997.10060403.x"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1997.10060406.x"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7329"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7718"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2632"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8994"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.05.014"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12302"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12420"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12463"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365920"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4883"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5433"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20285"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.12.003"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.5675","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.5675","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pd.5675","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.5675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T04:19:02Z","timestamp":1693973942000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.5675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,9]]},"references-count":59,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1002\/pd.5675"],"URL":"https:\/\/doi.org\/10.1002\/pd.5675","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,9]]},"assertion":[{"value":"2019-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}