{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:07:08Z","timestamp":1782958028368,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,2,3]],"date-time":"2003-02-03T00:00:00Z","timestamp":1044230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To display and compare the different published formulae that specify the association between maternal age and the risk of a Down syndrome live birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Papers published since 1987 on the prevalence of Down syndrome live births in relation to maternal age were located using MEDLINE and the references given in other papers. The data series and the models fitted to them were plotted to obtain a visual idea of their similarities and differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The observed and modelled age\u2010specific rates for Down syndrome births were remarkably similar in all published series of data for women up to the age of 35, were reasonably similar for women aged 35 to 45, but differed for women older than 45.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In practice, the overall small differences in age\u2010related risk between the different studies did not materially affect the performance of antenatal screening for Down syndrome. If a choice is to be made, the analysis based on the National Down Syndrome Cytogenetic Register (NDSCR) has marginal advantages since it is based on the largest data set and the corresponding model fits the data well. More data is needed to clarify the pattern of risk with maternal age among women over 45 years of age. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.568","type":"journal-article","created":{"date-parts":[[2003,3,18]],"date-time":"2003-03-18T16:10:50Z","timestamp":1048003850000},"page":"252-258","source":"Crossref","is-referenced-by-count":63,"title":["Comparison of models of maternal age\u2010specific risk for Down syndrome live births"],"prefix":"10.1002","volume":"23","author":[{"given":"J. K.","family":"Morris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. J.","family":"Wald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. E.","family":"Mutton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Alberman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,2,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199801)18:1<9::AID-PD210>3.0.CO;2-F"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1987.tb03115.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199811)18:11<1127::AID-PD419>3.0.CO;2-5"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jms.9.4.192"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970150509"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970140814"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960424)62:4<376::AID-AJMG10>3.0.CO;2-L"},{"key":"e_1_2_1_9_1","series-title":"Numerical Taxonomy of Birth Defects and Polygenic Disorders, Birth Defects Original Articles Series","first-page":"123","author":"Hook EB","year":"1977"},{"key":"e_1_2_1_10_1","first-page":"19","article-title":"Down syndrome in live births by singly year maternal age interval in a Swedish study: comparison with results from a New York State study","volume":"20","author":"Hook EB","year":"1978","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420170303"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(200002)20:2<169::AID-PD771>3.0.CO;2-W"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/096914139700400205"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jms.5.4.213"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.71.12.1367"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.35.6.482"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00278979"},{"key":"e_1_2_1_18_1","unstructured":"KoulischerL GillerotY LefevreM LamyM MancusoS.1991.Down syndrome: prenatal diagnosis and incidence at birth. 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