{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:09:36Z","timestamp":1758121776005,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T00:00:00Z","timestamp":1585785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare length of stay of the initial neonatal hospitalization and mortality across multiple stages of surgical palliation for infants with left\u2010sided obstructive lesions and severely restrictive or intact atrial septum (I\/RAS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective cohort study of patients prenatally diagnosed with left\u2010sided obstructive lesions and I\/RAS, defined by fetal pulmonary venous Dopplers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 76 fetal patients with 59 live born intending to pursue intervention. Those with I\/RAS had longer durations of mechanical ventilation (<jats:italic>P<\/jats:italic> =\u2009.031) but no difference in intensive care unit or total length of stay. Survival to discharge from neonatal hospitalization was 41.7% in the I\/RAS group and 80.7% in the unrestrictive group (<jats:italic>P<\/jats:italic> =\u2009.001). There was a higher proportion of deaths between stage 1 and stage 2 in the I\/RAS group \u2010 5\/9 (55.6%) vs 9\/50 (18%) in the unrestrictive group (<jats:italic>P<\/jats:italic> =\u2009.027). Beyond stage 2 palliation there was trend toward a difference in overall mortality (66.7% in I\/RAS vs 35.7% in unrestrictive, <jats:italic>P<\/jats:italic> =\u2009.05) but no statistically significant difference in transplant\u2010free survival (33.3% in I\/RAS vs 53.5% in unrestrictive, <jats:italic>P<\/jats:italic> =\u2009.11).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The survival disadvantage conferred by prenatally diagnosed severe atrial septal restriction is most pronounced in the neonatal and early infancy period, with no detectable difference in late midterm transplant\u2010free survival in our cohort.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5682","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T13:37:38Z","timestamp":1584365858000},"page":"776-784","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pulmonary venous Doppler patterns and <scp>midterm<\/scp> outcomes in fetuses with <scp>left\u2010sided<\/scp> obstructive lesions and restrictive atrial septum"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2417-131X","authenticated-orcid":false,"given":"Kristin","family":"Schneider","sequence":"first","affiliation":[{"name":"The Heart Institute, Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunice","family":"Hahn","sequence":"additional","affiliation":[{"name":"The Heart Institute, Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Statile","sequence":"additional","affiliation":[{"name":"The Heart Institute, Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russel","family":"Hirsch","sequence":"additional","affiliation":[{"name":"The Heart Institute, Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip R.","family":"Khoury","sequence":"additional","affiliation":[{"name":"The Heart Institute, Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Cnota","sequence":"additional","affiliation":[{"name":"The Heart Institute, Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Divanovic","sequence":"additional","affiliation":[{"name":"The Heart Institute, Cincinnati Children's Hospital Medical Center  Cincinnati Ohio 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