{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T08:53:52Z","timestamp":1784364832505,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:00:00Z","timestamp":1586908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate whether perioperative fetal hemodynamic changes in twin\u2010to\u2010twin transfusion syndrome (TTTS) are associated with neurodevelopmental impairment (NDI) at two years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Doppler parameters of three sonograms (day before, first day after and 1 week after laser surgery for TTTS) were assessed for correlation with neurodevelopmental outcome at two years (2008\u20102016). NDI was defined as: cerebral palsy, deafness, blindness, and\/or a Bayley\u2010III cognitive\/motor developmental test\u2010score\u2009&gt;\u20092SD below the mean.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Long\u2010term outcome was assessed in 492 TTTS survivors. NDI was present in 5% (24\/492). After adjustment for severe cerebral injury (present in 4%), associated with NDI were: middle cerebral artery peak systolic velocity (MCA\u2010PSV) &gt;1.5 multiples of the median (MoM) 1 day after surgery (odds ratio [OR] 4.96; 95% confidence interval [CI]: 1.17\u201021.05, <jats:italic>P<\/jats:italic> = .03), a change from normal umbilical artery pulsatility index (UA\u2010PI) presurgery to UA\u2010PI &gt;p95 postsurgery (OR 4.19; 95% CI: 1.04\u201016.87, <jats:italic>P<\/jats:italic> = .04), a change from normal to MCA\u2010PSV &gt;1.5MoM (OR 4.75; 95% CI: 1.43\u201015.77, <jats:italic>P<\/jats:italic> = .01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Perioperative fetal hemodynamic changes in TTTS pregnancies treated with laser are associated with poor neurodevelopmental outcome. Prospective research on the cerebrovascular response to altered hemodynamic conditions is necessary to further understand the cerebral autoregulatory capacity of the fetus in relation to neurodevelopmental outcome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5690","type":"journal-article","created":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T10:50:07Z","timestamp":1586343007000},"page":"825-830","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Perioperative fetal hemodynamic changes in twin\u2010twin transfusion syndrome and neurodevelopmental outcome at two years of age"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5345-5701","authenticated-orcid":false,"given":"Manon","family":"Gijtenbeek","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Division of Fetal Medicine Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique C.","family":"Haak","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Division of Fetal Medicine Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom J. P.","family":"Huberts","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Division of Fetal Medicine Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna M.","family":"Middeldorp","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Division of Fetal Medicine Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans J. C. M.","family":"Klumper","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Division of Fetal Medicine Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Femke","family":"Slaghekke","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Division of Fetal Medicine Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Lopriore","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick","family":"Oepkes","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Division of Fetal Medicine Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanine M. M.","family":"van Klink","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2797"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62419-8"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17520"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/thg.2016.26"},{"key":"e_1_2_10_6_1","first-page":"540.e541","article-title":"Improvement in neurodevelopmental outcome in survivors of twin\u2010twin transfusion syndrome treated with laser surgery","volume":"210","author":"Klink JM","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004-282X20160032"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14722"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4713"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-5629(95)00025-M"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/thg.2016.25"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000098715"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0000000000000128"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7200292"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000304512"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1868"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200001063420102"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2913"},{"key":"e_1_2_10_19_1","first-page":"404","volume-title":"Neurology of the Newborn","author":"Volpe JJ","year":"1995"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(05)80189-5"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.56.12.900"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8081226"},{"key":"e_1_2_10_23_1","volume-title":"Bayley scales of infant and toddler development","author":"Bayley N","year":"2006"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1997.tb07414.x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2010.133"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2006.25.4.449"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2907"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000178531"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000091361"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5280"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.13435"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70344-8"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6661(200003\/04)9:2<89::AID-MFM1>3.0.CO;2-1"},{"key":"e_1_2_10_35_1","first-page":"705","article-title":"Cerebral and umbilical arterial blood flow velocity waveforms in normal and growth\u2010retarded pregnancies","volume":"69","author":"Wladimiroff JW","year":"1987","journal-title":"Obstet Gynecol"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-306191"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.5690","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.5690","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pd.5690","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.5690","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T05:00:51Z","timestamp":1693976451000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.5690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,15]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1002\/pd.5690"],"URL":"https:\/\/doi.org\/10.1002\/pd.5690","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,15]]},"assertion":[{"value":"2019-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}