{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:50:28Z","timestamp":1747151428433,"version":"3.40.5"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T00:00:00Z","timestamp":1589673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007831","name":"Capital Health","doi-asserted-by":"publisher","award":["2018\u20102\u20104083"],"award-info":[{"award-number":["2018\u20102\u20104083"]}],"id":[{"id":"10.13039\/100007831","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Establish a fetal heart anatomical cross\u2010sectional database that correlates with screening transverse ultrasound images suggested by international professional organizations to detect congenital heart defects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fetuses with suspected congenital heart defects identified using the following cardiac image sequences obtained from transverse slices beginning from the upper abdomen and ending in the upper thorax were the subjects of this study: (1) four\u2010chamber view, (2) left ventricular outflow tract view, (3) three\u2010vessel right ventricular outflow tract view, and (4) the three\u2010vessel tracheal view. A database of digital two\u2010dimensional images of the transverse sweep was created for fetuses with confirmed congenital heart defects. In addition, using four\u2010dimensional ultrasound spatial\u2010temporal image correlation, selected transverse ultrasound images were acquired as part of the database. Ultrasound\u2010detected congenital heart defects were confirmed postnatally from pathological specimens of the heart and lungs using a cross\u2010sectional technique that mirrored the ultrasound images described above. When anatomical specimens were not available, prenatal ultrasound\u2010detected congenital heart defects were confirmed using postnatal echocardiography and\/or following surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The four screening views described in the Methods section identified 160 fetuses that comprised the database. Forty\u2010five datasets consisted of both ultrasound and anatomical cross\u2010sectional images. Thirteen percent (6\/45) only had abnormalities of the four\u2010chamber view (eg, endocardial cushion defects). Twenty\u2010four percent (11\/45) had abnormalities of the four\u2010chamber view as well as right and left outflow tracts (eg, complex malformations). Of these, 10 of 11 had an abnormal tracheal view. Sixteen percent (7\/45) had an abnormal four\u2010chamber view and abnormal right outflow tract (eg, pulmonary stenosis). Thirty\u2010three percent (15\/45) had a normal four\u2010chamber view but had abnormal right and left outflow tracts as well as an abnormal tracheal view (eg, tetralogy of Fallot, D\u2010transposition of the great arteries).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Combining both ultrasound and anatomical imaging may be of assistance in training imagers to recognize cardiovascular pathology when performing the screening examination of the fetal heart.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5708","type":"journal-article","created":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T20:50:00Z","timestamp":1586724600000},"page":"892-904","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The construction and application of an ultrasound and anatomical <scp>cross\u2010sectional<\/scp> database of structural malformations of the fetal heart"],"prefix":"10.1002","volume":"40","author":[{"given":"Zhen\u2010Juan","family":"Yang","sequence":"first","affiliation":[{"name":"Division of Obstetric Ultrasonography, Department of Obstetrics and Gynecology Peking University People's Hospital  Beijing P.R. 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