{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:47:51Z","timestamp":1771548471109,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T00:00:00Z","timestamp":1589328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007786","name":"National Center for Child Health and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007786","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Data on neurodevelopmental outcomes of children surviving after fetoscopic laser surgery (FLS) for twin\u2010to\u2010twin transfusion syndrome (TTTS) are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively investigated children surviving after FLS for TTTS at 16 to 26\u2009weeks' gestation between 2003 and 2014. Children were evaluated by standardized neurologic examinations using the Kyoto Scale 2001 at a corrected age of 3\u2009years \u00b1\u20096 months. Neurodevelopmental impairment (NDI) was defined as cerebral palsy (CP), bilateral blindness, bilateral deafness or a developmental quotient (DQ)\u2009&lt;\u200970 points. Brain magnetic resonance imaging (MRI) was performed at term\u2010equivalent age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 188 children from 110 twin pregnancies were evaluated. NDI was detected in 16\/188 (8.5%) children, including six cases of CP (3.2%). No children had bilateral blindness or deafness. An earlier gestational age at delivery was associated with a higher incidence of NDI (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Abnormal brain MRI findings were detected in 9\/16 (56%) of children with NDI, including 6\/6 (100%) with CP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The incidence of NDI in children following FLS at 3\u2009years old was 8.5%. Prematurity is a strong risk factor for NDI. Brain MRI may predict the development of CP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5726","type":"journal-article","created":{"date-parts":[[2020,5,3]],"date-time":"2020-05-03T05:07:06Z","timestamp":1588482426000},"page":"1013-1019","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Neurodevelopmental impairment at 3\u2009years of age after fetoscopic laser surgery for twin\u2010to\u2010twin transfusion syndrome"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8260-2336","authenticated-orcid":false,"given":"Sachio","family":"Matsushima","sequence":"first","affiliation":[{"name":"Division of Fetal Medicine, Center for Maternal\u2010Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8728-5576","authenticated-orcid":false,"given":"Katsusuke","family":"Ozawa","sequence":"additional","affiliation":[{"name":"Division of Fetal Medicine, Center for Maternal\u2010Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rika","family":"Sugibayashi","sequence":"additional","affiliation":[{"name":"Division of Fetal Medicine, Center for Maternal\u2010Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0997-2845","authenticated-orcid":false,"given":"Kohei","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Division of Obstetrics, Center for Maternal\u2010Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Tsukamoto","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Center for Maternal\u2010Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Radiology National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8654-6623","authenticated-orcid":false,"given":"Seiji","family":"Wada","sequence":"additional","affiliation":[{"name":"Division of Fetal Medicine, Center for Maternal\u2010Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development  Tokyo 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