{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T07:43:03Z","timestamp":1782459783038,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,5,24]],"date-time":"2020-05-24T00:00:00Z","timestamp":1590278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>In gastroschisis, there is evidence to suggest that gut dysfunction develops secondary to bowel inflammation; we aimed to evaluate the effect of maternal antenatal corticosteroids administered for obstetric reasons on time to full enteral feeds in a multicenter cohort study of gastroschisis infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A three center, retrospective cohort study (1992\u20102013) with linked fetal\/neonatal gastroschisis data was conducted. The primary outcome measure was time to full enteral feeds (a surrogate measure for bowel function) and secondary outcome measure was length of hospital stay. Analysis included Mann\u2010Whitney and Cox regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 500 patients included in the study, 69 (GA at birth 34 [25\u201038] weeks) received antenatal corticosteroids and 431 (GA at birth 37 [31\u201041] weeks) did not. Antenatal corticosteroids had no effect on the rate of reaching full feeds (Hazard ratio HR 1.0 [95% CI: 0.8\u20101.4]). However, complex gastroschisis (HR 0.3 [95% CI: 0.2\u20100.4]) was associated with an increased time to reach full feeds and later GA at birth (HR 1.1 per week increase in GA [95% CI: 1.1\u20101.2]) was associated with a decreased time to reach full feeds.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Maternal antenatal corticosteroids use, under current antenatal steroid protocols, in gastroschisis is not associated with an improvement in neonatal outcomes such as time to full enteral feeds or length of hospital stay.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5727","type":"journal-article","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T11:29:27Z","timestamp":1589369367000},"page":"991-997","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Antenatal corticosteroids and outcomes in gastroschisis: A multicenter retrospective cohort study"],"prefix":"10.1002","volume":"40","author":[{"given":"Helen","family":"Carnaghan","sequence":"first","affiliation":[{"name":"UCL Great Ormond Street Institute of Child Health and Great Ormond Street Hospital for Children  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine P.","family":"James","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit University College London Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul B.","family":"Charlesworth","sequence":"additional","affiliation":[{"name":"Paediatric Surgery Unit King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Ghionzoli","sequence":"additional","affiliation":[{"name":"UCL Great Ormond Street Institute of Child Health and Great Ormond Street Hospital for Children  London 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Coppi","sequence":"additional","affiliation":[{"name":"UCL Great Ormond Street Institute of Child Health and Great Ormond Street Hospital for Children  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Ryan","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit Mount Sinai Hospital, University of Toronto  Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakesh S.","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Neonatology Mount Sinai Hospital, University of Toronto  Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Davenport","sequence":"additional","affiliation":[{"name":"Paediatric Surgery Unit King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna L.","family":"David","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit University College London Hospital  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