{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:04:37Z","timestamp":1778717077605,"version":"3.51.4"},"reference-count":6,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To ascertain the perinatal outcomes for an apparently isolated exomphalos detected by prenatal ultrasound.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Our dataset captures cases from 614\u2009321 births in the Wessex region of England and the Channel Isles on all cases of pre\u2010 or postnatally diagnosed exomphalos from 1994 to 2015. Ascertainment was &gt;95%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three hundred and thirty five cases were reported to the register: 28 (8%) were not detected prenatally, 18 (6%) had already died in utero, 169 (55%) cases were found to have additional anomalies on first tertiary ultrasound scan and one case was lost to follow\u2010up. Therefore 119 (39%) cases had an apparently isolated exomphalos.<\/jats:p><jats:p>Of the 119 cases with only an exomphalos detected on first tertiary ultrasound scan, 25 (21%) had a chromosome abnormality. Of those with a normal or untested karyotype, 61% were confirmed to be an isolated anomaly after birth, 13% had an additional heart abnormality, 9% had Beckwith\u2010Wiedemann syndrome and 11% had additional problems diagnosed postnatally.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our large population\u2010based dataset with an average of 1\u2009year's postnatal follow\u2010up suggests that more than one\u2010third of apparently isolated prenatal cases of exomphalos will have an additional finding detected after birth. These data should help assist clinicians in their prenatal counseling.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5782","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T03:37:37Z","timestamp":1594265857000},"page":"1310-1314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Exomphalos without other prenatally detected anomalies: Perinatal outcomes from 22\u2009years of population\u2010based data"],"prefix":"10.1002","volume":"40","author":[{"given":"Rose","family":"Grover","sequence":"first","affiliation":[{"name":"Wessex Clinical Genetics Service Princess Anne Hospital  Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda L.","family":"Collins","sequence":"additional","affiliation":[{"name":"Wessex Clinical Genetics Service Princess Anne Hospital  Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9463-3188","authenticated-orcid":false,"given":"Diana","family":"Wellesley","sequence":"additional","affiliation":[{"name":"Wessex Clinical Genetics Service Princess Anne Hospital  Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1258\/jms.2011.010139"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.192310.4.4"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10048"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.04.015"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2009.01036.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.78.3.F209"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.5782","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.5782","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pd.5782","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.5782","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T04:17:52Z","timestamp":1693887472000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.5782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,23]]},"references-count":6,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1002\/pd.5782"],"URL":"https:\/\/doi.org\/10.1002\/pd.5782","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,23]]},"assertion":[{"value":"2020-01-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}