{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T15:56:28Z","timestamp":1768146988032,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Data suggest fetuses with congenital heart disease (CHD) have placental abnormalities. Their abnormal placental vasculature may affect fetal placental blood flow, which has not previously been explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We performed a retrospective cross\u2010sectional study comparing umbilical venous volume flow (UVVF) of single ventricle, D\u2010transposition of the great arteries, and tetralogy of Fallot fetuses with fetuses without CHD. UVVF and combined cardiac output (CCO) were calculated from fetal echocardiography and compared using <jats:italic>t<\/jats:italic> tests, <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> and Fisher's exact tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean gestational age and fetal weight were greater in CHD fetuses (26.5\u2009weeks, 1119.4 g; n = 81, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) compared to controls (23.1\u2009weeks, 675\u2009g; n = 170, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). UVVF\/fetal weight was nevertheless decreased among cases (99.8 vs 115.3 mL\/min\/kg, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Subgroup analysis of 20\u2010 to 25\u2010week fetuses demonstrated no significant differences in case and control baseline characteristics. In CHD fetuses (n = 31) compared to controls (n = 144), absolute UVVF (50.8 vs 62.1 mL\/min, <jats:italic>P<\/jats:italic> = .006), and UVVF\/fetal weight (98.8 vs 118.5 mL\/min\/kg, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) were decreased. Findings were similar in single ventricle (n = 24) and hypoplastic left heart syndrome (n = 14).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Mid\u2010gestational placental blood flow in CHD fetuses is decreased compared to controls. Further study is needed to explore the relationship between UVVF and placental pathology, and impact on outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5791","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T20:43:12Z","timestamp":1594932192000},"page":"1432-1438","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["<scp>Mid\u2010gestational<\/scp> fetal placental blood flow is diminished in the fetus with congenital heart disease"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5805-769X","authenticated-orcid":false,"given":"Deborah Y.","family":"Ho","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics Stanford University School of Medicine  Palo Alto California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Josowitz","sequence":"additional","affiliation":[{"name":"Fetal Heart Program Division of Pediatric Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Katcoff","sequence":"additional","affiliation":[{"name":"Healthcare Analytics Unit The Children's Hospital of Philadelphia  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather M.","family":"Griffis","sequence":"additional","affiliation":[{"name":"Healthcare Analytics Unit The Children's Hospital of Philadelphia  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyun","family":"Tian","sequence":"additional","affiliation":[{"name":"Fetal Heart Program Division of Pediatric Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. William","family":"Gaynor","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiothoracic Surgery The Children's Hospital of Philadelphia  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Rychik","sequence":"additional","affiliation":[{"name":"Fetal Heart Program Division of Pediatric Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2013.05.003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht389"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.024600"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.12505"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12252"},{"key":"e_1_2_9_7_1","first-page":"1","article-title":"Placenta\u2010related complications in women carrying a foetus with congenital heart disease","volume":"29","author":"Ruiz A","year":"2016","journal-title":"J Matern Neonatal Med"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-018-1876-x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19102"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.21970"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2012.31.12.1927"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5306"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00671.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1375\/twin.14.2.192"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.956"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11147"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.11.032"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12919"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.10.025"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.034467"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2013.07.063"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezy015"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7730"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1091"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753495X18775898"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.5791","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.5791","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pd.5791","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.5791","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T21:25:23Z","timestamp":1693862723000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.5791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,9]]},"references-count":24,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1002\/pd.5791"],"URL":"https:\/\/doi.org\/10.1002\/pd.5791","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,9]]},"assertion":[{"value":"2020-05-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}