{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:57:30Z","timestamp":1790564250072,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T00:00:00Z","timestamp":1597622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to define the prenatal ultrasound semiology of cleft palate without cleft lip using 3D visualization of the fetal palate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective longitudinal study was performed in our University Hospital Center from 2011 to 2018. The fetal secondary palate was studied in 3D, starting with 2D axial transverse ultrasound view. We defined a cleft palate as a disruption of the horizontal plate of the palatine bone of the secondary palate. Prenatal findings were correlated to anatomic postnatal examinations performed by a paediatric plastic surgeon.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010three cases of cleft palate without cleft lip were prenatally diagnosed, of whom 34 were associated with malformations. We defined four types of disruptive appearances: isolated nonvisualization of the posterior nasal spine; partial\u2010disruption or cleft velum; complete disappearance or V\u2010shaped cleft palate; and complete disappearance or U\u2010shaped cleft palate. The adjusted kappa coefficient, between prenatal and postnatal evaluation, was 0.88 (95% CI: 0.79\u20100.97), corresponding to an excellent agreement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Using a strictly axial transverse ultrasound view, visualization of the secondary fetal palate enables to diagnose a cleft palate without cleft lip. This method offers a prenatal anatomic classification of cleft palate with a high level of concordance to postnatal findings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5794","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T20:41:48Z","timestamp":1594932108000},"page":"1447-1458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Prenatal ultrasound diagnosis of cleft palate without cleft lip, the new ultrasound semiology"],"prefix":"10.1002","volume":"40","author":[{"given":"Jean Michel","family":"Faure","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital Center  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve","family":"Mousty","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital Center  N\u00eemes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mich\u00e8le","family":"Bigorre","sequence":"additional","affiliation":[{"name":"Department of Plastic Pediatric and Craniofacial Surgery University Hospital Center  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance","family":"Wells","sequence":"additional","affiliation":[{"name":"Department of Genetic University Hospital Center  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Boulot","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital Center  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Captier","sequence":"additional","affiliation":[{"name":"Department of Plastic Pediatric and Craniofacial Surgery University Hospital Center  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3530-6328","authenticated-orcid":false,"given":"Florent","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital Center  Montpellier France"},{"name":"Inserm Center for Research in Epidemiology and Population Health (CESP)  Villejuif France"},{"name":"EA2415, Epidemiologic Biostatistic and Clinical Research Laboratory University of Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,17]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Conf\u00e9rence Nationale d'Echographie Obst\u00e9tricale et F\u0153tale \u2013 L'\u00e9chographie de d\u00e9pistage pr\u00e9natal","author":"CNEOF.net","year":"2016"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1597\/09-217"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8831"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7472"},{"key":"e_1_2_9_6_1","unstructured":"EUROCAT website database. 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