{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T13:47:49Z","timestamp":1780062469612,"version":"3.54.0"},"reference-count":89,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,8,22]],"date-time":"2020-08-22T00:00:00Z","timestamp":1598054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Worldwide, about 150\u2009000 infants are born with spina bifida yearly, making this condition one of the most common fetal central nervous system anomalies compatible with life. Over the last decade, major changes have been introduced in the prenatal diagnosis and management of spina bifida. In this review, we provide a brief summary of the current management of fetal spina bifida and present essential information that should be provided to expecting parents when their fetus has been diagnosed with spina bifida. This information is focused around common parental questions, as encountered in our typical clinical practice, to facilitate knowledge translation.<\/jats:p>","DOI":"10.1002\/pd.5802","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T13:58:23Z","timestamp":1595339903000},"page":"1499-1507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Fetal spina bifida: What we tell the parents"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0435-5728","authenticated-orcid":false,"given":"Lara","family":"Gotha","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Mount Sinai Hospital and University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vagisha","family":"Pruthi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Mount Sinai Hospital and University of Toronto  Toronto Canada"},{"name":"Ontario Fetal Centre  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4426-7631","authenticated-orcid":false,"given":"Nimrah","family":"Abbasi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Mount Sinai Hospital and University of Toronto  Toronto Canada"},{"name":"Ontario Fetal Centre  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhaya V.","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Ontario Fetal Centre  Toronto Canada"},{"name":"Division of Neurosurgery Hospital for Sick Children and University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paige","family":"Church","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sunnybrook Health Sciences Centre Holland\u2010Bloorview Kids Rehabilitation Hospital and University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Drake","sequence":"additional","affiliation":[{"name":"Ontario Fetal Centre  Toronto Canada"},{"name":"Division of Neurosurgery Hospital for Sick Children and University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose C.A.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Ontario Fetal Centre  Toronto Canada"},{"name":"Department of Anesthesia Mount Sinai Hospital and University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yenge","family":"Diambomba","sequence":"additional","affiliation":[{"name":"Ontario Fetal Centre  Toronto Canada"},{"name":"Department of Pediatrics Mount Sinai Hospital and University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varsha","family":"Thakur","sequence":"additional","affiliation":[{"name":"Ontario Fetal Centre  Toronto Canada"},{"name":"Department of Cardiology Hospital for Sick Children and University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Mount Sinai Hospital and University of Toronto  Toronto Canada"},{"name":"Ontario Fetal Centre  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3034-6905","authenticated-orcid":false,"given":"Tim","family":"Van Mieghem","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Mount Sinai Hospital and University of Toronto  Toronto Canada"},{"name":"Ontario Fetal Centre  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,22]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-062012-170354"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20136"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2010.03.042"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.7"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h5949"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12354"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23372"},{"issue":"1","key":"e_1_2_13_9_1","first-page":"1","article-title":"Updated estimates of neural tube defects prevented by mandatory folic acid fortification \u2013 United States, 1995\u20102011","volume":"64","author":"Williams J","year":"2015","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067103"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23153"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03530210052030"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2008.04.010"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20210"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35430"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1173"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCD.0b013e328348d99d"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1028-4559(08)60002-9"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1028-4559(08)60003-0"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5390"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2016.03.008"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.05.047"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.113"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)90908-4"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101287200"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011303432204"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(05)70083-X"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9203985"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-199910000-00014"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.964"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.117676"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.853"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-017-3443-9"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7329"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4883"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.05.014"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(15)30444-8"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1159\/000335677"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4280"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1028-4559(08)60070-4"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2015.1019456"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2002.21.6.619"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15732"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1159\/000028916"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1159\/000264297"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3909"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2755"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.12126"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.02.005"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5466"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.3109\/01443615.2015.1030597"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(97)00090-X"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014379"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15342"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-36866"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yapd.2014.03.007"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20215"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013325"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.09.094"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000000404"},{"issue":"2","key":"e_1_2_13_61_1","first-page":"110","article-title":"Levels of mobility in children and adolescents with spina bifida \u2013clinical parameters predicting mobility and maintenance of these skills","volume":"23","author":"Pauly M","year":"2013","journal-title":"Eur J Pediatr Surg"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2016.08.003"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000334"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2018.05.023"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.03.107"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2016.07.081"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.11.048"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cppeds.2017.06.007"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2016.11.052"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23525"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2015.02.010"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753495X18769221"},{"issue":"7","key":"e_1_2_13_73_1","first-page":"e32","article-title":"The association between urinary continence and quality of life in pediatric patients with spina bifida and tethered cord","volume":"18","author":"Olesen JD","year":"2013","journal-title":"Pediatr Child Health"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/cch.12367"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0495-342"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)00021-5"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23174"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.06.034"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.04.005"},{"key":"e_1_2_13_80_1","first-page":"1","article-title":"Intrauterine closure of myelomeningocele is associated with superior long\u2010term quality of life than postnatal closure: a single\u2010center study","author":"Mummareddy N","year":"2019","journal-title":"J Neurosurg Pediatr"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0000000000000346"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.03.029"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.03.008"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1159\/000500451"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365214"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13430"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001941"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20308"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002577"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(15)30230-9"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.5802","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.5802","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pd.5802","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.5802","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T07:53:55Z","timestamp":1693814035000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.5802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,22]]},"references-count":89,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1002\/pd.5802"],"URL":"https:\/\/doi.org\/10.1002\/pd.5802","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,22]]},"assertion":[{"value":"2019-11-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}