{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T06:04:20Z","timestamp":1769061860329,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:00:00Z","timestamp":1598486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Since prenatal diagnosis of isolated clubfoot has a false positive rate (FP) of 10%\u201040%, fetal parameters that might correlate with post\u2010natal confirmation and grade of severity were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Retrospective analysis (2013\u20102019) of cases analysed with three\u2010dimensional multiplanar view. The following data were recorded: the angle between the long axis of foot and lower leg; width, length and width\u2010to\u2010length ratio (W\/L) of the foot; tibia length and calf width (T\/C) ratio. Severity after birth was assessed using the Pirani classification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Diagnosis was confirmed in 45\/53 neonates (84.9%, FP 15%). Values were higher for both angle and W\/L in true vs false positive cases (median angle 100.4\u00b0 versus 69.55\u00b0, <jats:italic>p<\/jats:italic> &lt;.000; median W\/L 0.53 vs 0.45, <jats:italic>p<\/jats:italic> = .001), no difference for T\/C (3.77 vs 3.48, <jats:italic>p<\/jats:italic> = .8). The area under the curve for angle was 0.98 (CI 0.94\u20101.00), with a diagnostic cut\u2010off of 84.7\u00b0 (PPV of 100%, NPV of 66.7%). Median Pirani score, available for 33 neonates (73.3%) was 3 (IQR 3\u20104): only angle correlated with Pirani score (Spearman coefficient 0.36, <jats:italic>p<\/jats:italic> = .04)<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Measuring the angle between the foot and lower leg can reduce the FP rate of prenatal congenital clubfoot diagnosis and better predict the need for postnatal treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5808","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T02:23:56Z","timestamp":1597199036000},"page":"1547-1552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Congenital isolated clubfoot: Correlation between prenatal assessment and postnatal degree of severity"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0765-1298","authenticated-orcid":false,"given":"Mariano","family":"Lanna","sequence":"first","affiliation":[{"name":"Fetal Therapy Unit \u201cU.Nicolini\u201d, Department of Obstetrics and Gynecology Buzzi Children's Hospital, University of Milan  Milan Italy"},{"name":"Department of Obstetrics and Gynecology Buzzi Children's Hospital, University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Casati","sequence":"additional","affiliation":[{"name":"Fetal Therapy Unit \u201cU.Nicolini\u201d, Department of Obstetrics and Gynecology Buzzi Children's Hospital, University of Milan  Milan Italy"},{"name":"Department of Obstetrics and Gynecology Buzzi Children's Hospital, University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clelia","family":"Torre","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Buzzi Children's Hospital, University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Monforte","sequence":"additional","affiliation":[{"name":"Pediatric Orthopedic Department Buzzi Children's Hospital, University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Andreacchio","sequence":"additional","affiliation":[{"name":"Pediatric Orthopedic Department Buzzi Children's Hospital, University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Faiola","sequence":"additional","affiliation":[{"name":"Fetal Therapy Unit \u201cU.Nicolini\u201d, Department of Obstetrics and Gynecology Buzzi Children's Hospital, University of Milan  Milan Italy"},{"name":"Department of Obstetrics and Gynecology Buzzi Children's Hospital, University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Cetin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Buzzi Children's Hospital, University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5760-5081","authenticated-orcid":false,"given":"MariaAngela","family":"Rustico","sequence":"additional","affiliation":[{"name":"Fetal Therapy Unit \u201cU.Nicolini\u201d, Department of Obstetrics and Gynecology Buzzi Children's Hospital, University of Milan  Milan Italy"},{"name":"Department of Obstetrics and Gynecology Buzzi Children's Hospital, University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35955"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.22275"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4534"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8831"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4079"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5077"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000354554"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2012.31.7.997"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2008.27.5.701"},{"key":"e_1_2_10_11_1","unstructured":"PiraniS OuterbridgeHK SawatzkiB StothersKA. Reliable method of clinically evaluating a virgin clubfoot evaluation. Paper presented at: 21st SICOT World Congress; 1999; Sydney Australia. Accessed April 18th to 23rd."},{"key":"e_1_2_10_12_1","volume-title":"Congenital Clubfoot: Fundamentals of Treatment","author":"Ponseti IV","year":"1996"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-196345020-00004"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.2.376"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.155.1.3883419"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.09.022"},{"issue":"6","key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1097\/BPO.0000000000000182","article-title":"Correlation of Pirani and Dimeglio scores with number of Ponseti casts required for clubfoot correction","volume":"34","author":"Gao R","year":"2014","journal-title":"J Pediatr Orthop"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-018-3873-3"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.88B8.17482"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8932"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.5808","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.5808","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pd.5808","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.5808","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T07:53:22Z","timestamp":1693814002000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.5808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,27]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1002\/pd.5808"],"URL":"https:\/\/doi.org\/10.1002\/pd.5808","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,27]]},"assertion":[{"value":"2020-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}