{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:17:22Z","timestamp":1780406242282,"version":"3.54.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T00:00:00Z","timestamp":1604361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Agenesis of the ductus venosus (ADV) has been associated with additional anomalies in up to 83% of cases. We sought to investigate characteristics, co\u2010morbidities and outcomes of ADV in the current era. We hypothesized that rates of cardiac and non\u2010cardiac diagnoses and survival would be higher, due to advances in genetic testing, prenatal diagnosis and surveillance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective series of cases diagnosed at our institution from 2007 to 2018 were identified by searching our database. Cardiac and obstetric charts were reviewed for cardiac and extra\u2010cardiac anomalies, genetic results and outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fourteen cases were diagnosed at a mean gestational age of 23.9\u2009weeks (range 13\u201033). All had associated genetic, cardiac or extra\u2010cardiac anomalies. Eight (57%) had cardiac anomalies and one other developed cardiomyopathy by 6\u2009months. Extra\u2010cardiac anomalies were present in 93% (13\/14) and genetic diagnoses made in 75% (6\/8) of those tested. Cardiac output <jats:italic>Z<\/jats:italic>\u2010scores were &gt;2 in 60% (6\/10) prior to delivery. Two had hydrops, there was one intra\u2010uterine death, 13 live\u2010births and two neonatal deaths.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our cohort had more associated diagnoses and a lower mortality than previously reported. In our experience, high output occurs frequently, however with a relatively low risk of hydrops and intrauterine death.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5827","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T07:48:32Z","timestamp":1604476112000},"page":"15-20","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prenatal features, associated co\u2010morbidities and clinical course of agenesis of the ductus venosus in the current era"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9733-5795","authenticated-orcid":false,"given":"Angela","family":"McBrien","sequence":"first","affiliation":[{"name":"Fetal and Neonatal Cardiology Program, Division of Pediatric Cardiology, Department of Pediatrics University of Alberta  Edmonton Alberta Canada"},{"name":"Women's and Children's Health Research Institute University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oana","family":"Caluseriu","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Y","family":"Niederhoffer","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa K","family":"Hornberger","sequence":"additional","affiliation":[{"name":"Fetal and Neonatal Cardiology Program, Division of Pediatric Cardiology, Department of Pediatrics University of Alberta  Edmonton Alberta Canada"},{"name":"Women's and Children's Health Research Institute University of Alberta  Edmonton Alberta Canada"},{"name":"Department of Obstetrics and Gynecology University of Alberta  Edmonton Alberta 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