{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:18:19Z","timestamp":1788412699614,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe obstetric and perinatal outcomes in cases of congenital Zika syndrome (CZS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A dual prospective and retrospective cohort study involving 102 pairs of mothers and fetuses\/children with CZS whose infection was confirmed by testing for the Zika virus in amniotic fluid, umbilical cord blood, and fragments from the placenta of the newborn infant (confirmed CZS), or by intrauterine imaging tests (neurosonography), and\/or postnatal computed tomography (presumed CZS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Suspicion of CZS was investigated by ultrasonography during pregnancy in 52.9% of cases. The principal prenatal imaging findings were ventriculomegaly (43.1%) and microcephaly (42.2%). Median gestational age at delivery was 39\u2009weeks, with 15.7% being premature. Mean head circumference at birth was 30.0\u2009\u00b1\u20092.3 cm, with 66% of cases being classified as having microcephaly. Arthrogryposis was found in 10 cases (9.8%). There were no fetal deaths; however, nine neonatal deaths were recorded, and three autopsies were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Neonatal mortality was high, almost 10%. Regarding the abnormalities of CZS, microcephaly, although common, was not present in all cases and intracranial findings need to be taken into consideration for diagnosis. Therefore, ultrasound screening during pregnancy should be systematized and expanded in endemic zones.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5831","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T05:39:16Z","timestamp":1600321156000},"page":"1732-1740","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Obstetric and perinatal outcomes in cases of congenital Zika syndrome"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8575-544X","authenticated-orcid":false,"given":"Adriana","family":"Melo","sequence":"first","affiliation":[{"name":"Instituto de Pesquisa Professor Amorim Neto (IPESQ)  Campina Grande Brazil"},{"name":"UNIFACISA  Campina Grande Brazil"},{"name":"Federal University of Campina Grande (UFCG)  Campina Grande Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jousilene","family":"de Sales Tavares","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Professor Amorim Neto (IPESQ)  Campina Grande Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianny","family":"de Assis Costa","sequence":"additional","affiliation":[{"name":"UNIFACISA  Campina Grande Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Santana de Aguiar","sequence":"additional","affiliation":[{"name":"Federal University of Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Malinger","sequence":"additional","affiliation":[{"name":"Lis Maternity Hospital, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"de Oliveira Melo","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Professor Amorim Neto (IPESQ)  Campina Grande Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Balbino da\u2010Silva","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Professor Amorim Neto (IPESQ)  Campina Grande Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Luiz Fonseca Schamber\u2010Reis","sequence":"additional","affiliation":[{"name":"UNIFACISA  Campina Grande Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Gama","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Professor Amorim Neto (IPESQ)  Campina Grande Brazil"},{"name":"UNIFACISA  Campina Grande Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amilcar","family":"Tanuri","sequence":"additional","affiliation":[{"name":"Federal University of Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Chimelli","sequence":"additional","affiliation":[{"name":"Instituto Estadual do C\u00e9rebro Paulo Niemeyer  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Oliveira\u2010Szejnfeld","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Instituto D'Or de Pesquisa (IDOR)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melania","family":"M. 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