{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T14:11:37Z","timestamp":1700230297016},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,3,5]],"date-time":"2003-03-05T00:00:00Z","timestamp":1046822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study presents 30 cases of fetal isolated <jats:italic>spina bifida aperta<\/jats:italic> (SBA) to identify prenatal ultrasound findings that could predict the prognosis. Comparisons between surviving patients who had normal (group 1) and abnormal (group 2) post\u2010natal neurological outcomes were made for three different prenatal signs, that is, site of vertebral lesion, presence and degree of ventriculomegaly and presence of talipes. The site of the lesion was the most significant outcome predictor, as high spinal dysraphisms were observed in 2 patients (2\/7\u201328.6%) in group 1 and in 15 patients (15\/19\u201379.0%) in group 2 (<jats:italic>p<\/jats:italic> = 0.03). The presence of fetal ventriculomegaly was associated with impaired post\u2010natal neurological development, as it occurred in 4 patients (4\/7\u201357.1%) in group 1 and in 18 patients (18\/19\u201394.7%) in group 2 (<jats:italic>p<\/jats:italic> = 0.04). The presence of talipes did not significantly differ between the two groups. Patients with abnormal intellectual outcome (8\/26\u201330.8%) had significantly greater (<jats:italic>p<\/jats:italic> = 0.018) lateral ventricle\/hemisphere ratios (mean = 0.74, standard deviation = 0.13) than those with normal intellectual development (mean = 0.54, standard deviation = 0.18). Mean post\u2010natal follow\u2010up was at 23 months (standard deviation = 15 months). Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pd.584","type":"journal-article","created":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T19:05:16Z","timestamp":1049223916000},"page":"311-314","source":"Crossref","is-referenced-by-count":19,"title":["Association between prenatal sonographic findings and post\u2010natal outcomes in 30 cases of isolated <i>spina bifida aperta<\/i>"],"prefix":"10.1002","volume":"23","author":[{"given":"Cleisson F\u00e1bio A.","family":"Peralta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Bunduki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 P\u00edndaro P.","family":"Plese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eberval Gadelha","family":"Figueiredo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Miguelez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Zugaib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,3,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1542\/peds.50.3.466","article-title":"Results of treatment of 171 consecutive myelomeningoceles\u20141963 to 1968","volume":"50","author":"Ames MD","year":"1972","journal-title":"Pediatrics"},{"key":"e_1_2_1_3_1","first-page":"26","article-title":"Fetal myelomeningocele. 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