{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T23:07:41Z","timestamp":1776985661142,"version":"3.51.4"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the incidence of structural and chromosomal abnormalities in cases of fetal edema on early ultrasound prior to non\u2010invasive prenatal testing (NIPT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study of women undergoing pre\u2010NIPT ultrasound with fetal crown\u2010rump length (CRL) of 28 to 44\u2009mm was conducted at a tertiary obstetric ultrasound clinic in Melbourne, Australia. Cases of reported fetal edema were included, and subclassified as isolated nuchal edema (&gt;2.2\u2009mm) or generalized edema\/hydrops by two operators blinded to outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 104 cases of fetal edema. Nuchal edema and generalized edema were present in 40 (38.5%) and 64 (61.5%) cases, respectively. Relevant chromosomal anomalies were identified in 19.2% (20\/104), occurring in 10.0% (4\/40) of the nuchal edema and 25.0% (16\/64) of the generalized edema\/hydrops cases. Structural anomalies with normal karyotype occurred in four (3.8%) additional cases. Miscarriage occurred in four cases (3.8%) and termination of pregnancy in 18 cases (17.3%). Among cases that reached the 11 to 13<jats:sup>+6<\/jats:sup> weeks ultrasound, the edema resolved in 81.9% and these cases had less adverse outcomes than those with NT\u22653.5\u2009mm (10.9% vs 76.5%, <jats:italic>P<\/jats:italic> &lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fetal edema in early pregnancy is associated with a high incidence of structural and\/or chromosomal abnormalities; these rates increase with progressive severity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5847","type":"journal-article","created":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T07:36:12Z","timestamp":1602920172000},"page":"241-247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Outcomes following the detection of fetal edema in early pregnancy prior to non\u2010invasive prenatal testing"],"prefix":"10.1002","volume":"41","author":[{"given":"Jayshree","family":"Ramkrishna","sequence":"first","affiliation":[{"name":"Monash Ultrasound for Women Monash IVF Group  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3854-0224","authenticated-orcid":false,"given":"Melody","family":"Menezes","sequence":"additional","affiliation":[{"name":"Monash Ultrasound for Women Monash IVF Group  Melbourne Australia"},{"name":"Department of Paediatrics The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kedar","family":"Humnabadkar","sequence":"additional","affiliation":[{"name":"Monash Ultrasound for Women Monash IVF Group  Melbourne Australia"},{"name":"Department of Obstetrics and Gynaecology Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl","family":"Tse","sequence":"additional","affiliation":[{"name":"Monash Ultrasound for Women Monash IVF Group  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria J.","family":"Maxfield","sequence":"additional","affiliation":[{"name":"Monash Ultrasound for Women Monash IVF Group  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabricio","family":"da Silva Costa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Monash University  Melbourne Victoria Australia"},{"name":"Department of Gynecology and Obstetrics Ribeir\u00e3o Preto Medical School, University of Sao Paulo, Ribeir\u00e3o Preto  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2263-3592","authenticated-orcid":false,"given":"Daniel L.","family":"Rolnik","sequence":"additional","affiliation":[{"name":"Monash Ultrasound for Women Monash IVF Group  Melbourne Australia"},{"name":"Department of Obstetrics and Gynaecology Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Meagher","sequence":"additional","affiliation":[{"name":"Monash Ultrasound for Women Monash IVF Group  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17484"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17483"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15995"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-017-4459-9"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13203"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000201946"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.16.01066"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000191301.63871.c6"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000201979.23031.32"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4799"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1103"}],"container-title":["Prenatal 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