{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T19:34:07Z","timestamp":1768419247714,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T00:00:00Z","timestamp":1610150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Ebstein anomaly and tricuspid valve dysplasia (EA\/TVD) carry high perinatal mortality. Past studies have focused on cardiac predictors of mortality; we sought to describe the fetal echo (FE) extracardiac Dopplers in this cohort and determine their association with perinatal mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Fetuses with EA\/TVD at 23 centers from 2005\u20132011 were included for retrospective study. Doppler pattern and velocity of the umbilical artery (UA), umbilical vein (UV), ductus venosus (DV), and middle cerebral artery (MCA) were collected. Bivariate and multivariate analyzes were performed. The primary outcome measure was perinatal mortality, defined as fetal demise or neonatal death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 190 cases that met eligibility criteria, alterations were seen in 50% of UA, 16% of UV, 48% of DV, and 8% of MCA Doppler indices on the last FE (median 27.4\u2009weeks). Independent predictors of perinatal mortality included abnormal UA Doppler pattern of absence or reversed end diastolic flow (OR 9.7) and UV velocity <jats:italic>z<\/jats:italic> score &lt;1 (OR 2.5), in addition to diagnosis &lt;32\u2009weeks (OR 4.2) and tricuspid valve (TV) annulus <jats:italic>z<\/jats:italic> score \u22656 (OR 5.3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Abnormal UA Doppler pattern and decreased UV velocity are independent predictors of perinatal mortality in EA\/TVD fetuses and should be used to refine mortality risk and guide perinatal management.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5873","type":"journal-article","created":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T17:54:02Z","timestamp":1606413242000},"page":"332-340","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Extracardiac Doppler indices predict perinatal mortality in fetuses with Ebstein anomaly and tricuspid valve dysplasia"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9104-9798","authenticated-orcid":false,"given":"Shuo","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology Children's Hospital Los Angeles, University of Southern California Keck School of Medicine  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay R.","family":"Freud","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology Hospital for Sick Children, University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Detterich","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology Children's Hospital Los Angeles, University of Southern California Keck School of Medicine  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita J.","family":"Moon\u2010Grady","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology Benioff Children's Hospital, University of California San Francisco School of Medicine  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary T.","family":"Donofrio","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology Children's National Medical Center, George Washington University School of Medicine and Health Sciences  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9012-6592","authenticated-orcid":false,"given":"Edgar T.","family":"Jaeggi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology Hospital for Sick Children, University of Toronto Faculty of Medicine  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita L.","family":"Szwast","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaine A.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology Texas Children's Hospital, Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Kavanaugh\u2010Mchugh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology Monroe Carell Jr. Children's Hospital, Vanderbilt University School of Medicine  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa W.","family":"Howley","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology The Children's Heart Clinic and Children's Minnesota  Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary E.","family":"van der Velde","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology C.S. 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