{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:44:43Z","timestamp":1787679883681,"version":"build-2784847793"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,3]],"date-time":"2021-01-03T00:00:00Z","timestamp":1609632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Congenital diarrheal disorders (CDDs) are a group of rare diseases among which some present as inherited disorders of intestinal electrolyte transportation: congenital chloride diarrhea (CCD) and congenital sodium diarrhea (CSD) with prenatal manifestations, mainly polyhydramnios, leading to premature delivery. Affected neonates present with watery stools, sometimes mistaken as urine, leading to a misdiagnosis of Bartter syndrome. The aim of this study was to study the value of a prenatal biochemical pattern in the case of suspected CDD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively studied 12 amniotic fluids of CDD\u2010affected fetuses prenatally suspected and confirmed after birth. Digestive enzymes, proteins, and electrolytes were assayed and showed abnormal biochemical patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 12 infants (eight CCD\u2010 and four CSD\u2010affected) were born prematurely with a normal birth weight. Electrolytes and the Bartter index were normal for all cases. Amniotic fluid enzyme patterns were abnormal: anal leakage for nine, as expected, but vomiting of bile was observed for three infants, for whom an occlusive syndrome required surgery, and thereafter severe complications appeared with a poor prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Amniotic fluid biochemical patterns differentiate CDD from Bartter syndrome. If a vomiting bile pattern is observed, postnatal management should take into account the hypothesis of a most severe complication.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5878","type":"journal-article","created":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:52:51Z","timestamp":1608684771000},"page":"434-439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prenatal biochemical diagnosis of two forms of congenital diarrheal disorders (congenital chloride diarrhea and congenital sodium diarrhea): A series of 12 cases"],"prefix":"10.1002","volume":"41","author":[{"given":"Laure","family":"Macraigne","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Biochimie Pr\u00e9natale Laboratoire de Biochimie\u2010Hormonologie H\u00f4pital Robert Debr\u00e9 AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bichr","family":"Allaf","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Biochimie Pr\u00e9natale Laboratoire de Biochimie\u2010Hormonologie H\u00f4pital Robert Debr\u00e9 AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Buffat","sequence":"additional","affiliation":[{"name":"D\u00e9partement de G\u00e9n\u00e9tique M\u00e9dicale H\u00f4pital Timone Enfants AP\u2013HM  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Spaggiari","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Maternal\u2010Fetal Medicine AP\u2010HP Necker Enfants\u2010Malades Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Dimitrov","sequence":"additional","affiliation":[{"name":"Pediatrics Unit Regional Hospital of Orleans  Orleans France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Fabre","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Nutrition Hospital La Timone AP\u2010HM  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8877-0381","authenticated-orcid":false,"given":"Jonathan","family":"Rosenblatt","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics AP\u2010HP Robert Debr\u00e9 Hospital University Paris Diderot and Paris Sorbonne\u2010Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1941-5516","authenticated-orcid":false,"given":"Sophie","family":"Dreux","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Biochimie Pr\u00e9natale Laboratoire de Biochimie\u2010Hormonologie H\u00f4pital Robert Debr\u00e9 AP\u2010HP  Paris 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