{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:38:48Z","timestamp":1787503128733,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Fetal aortic valvuloplasty (FAV) for severe aortic stenosis (AS) has shown promise in averting progression to hypoplastic left heart syndrome. After FAV, predicting which fetuses will achieve a biventricular (BiV) circulation after birth remains challenging. Identifying predictors of postnatal circulation on late gestation echocardiography will improve parental counseling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Liveborn patients who underwent FAV and had late gestation echocardiography available were included (2000\u20132017,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a096). Multivariable logistic regression and classification and regression tree analysis were utilized to identify independent predictors of BiV circulation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 96 fetuses, 50 (52.1%) had BiV circulation at the time of neonatal discharge. In multivariable analysis, independent predictors of biventricular circulation included left ventricular (LV) long axis z\u2010score (OR 3.2, 95% CI 1.8\u20135.7,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), LV ejection fraction (OR 1.3, 95% CI 1.0\u20131.8,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.023), anterograde aortic arch flow (OR 5.0, 95% CI 1.2\u201320.4,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.024), and bidirectional or right\u2010to\u2010left foramen ovale flow (OR 4.6, 95% CI 1.4\u201315.8,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.015).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Several anatomic and physiologic parameters in late gestation were found to be independent predictors of BiV circulation after FAV. Identifying these predictors adds to our understanding of LV growth and hemodynamics after FAV and may improve parental counseling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.5885","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T21:04:01Z","timestamp":1611003841000},"page":"479-485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Late gestation predictors of a postnatal biventricular circulation after fetal aortic valvuloplasty"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9197-1854","authenticated-orcid":false,"given":"Meaghan J.","family":"Beattie","sequence":"first","affiliation":[{"name":"Department of Cardiology Boston Children's Hospital  Boston Massachusetts USA"},{"name":"Department of Pediatrics Harvard Medical School  Boston Massachusetts USA"},{"name":"Division of Cardiology, Department of Pediatrics Lucile Packard Children's Hospital Stanford University School of Medicine  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3180-9764","authenticated-orcid":false,"given":"Kevin G.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Department of Cardiology Boston Children's Hospital  Boston Massachusetts USA"},{"name":"Department of Pediatrics Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn A.","family":"Sleeper","sequence":"additional","affiliation":[{"name":"Department of Cardiology Boston Children's Hospital  Boston Massachusetts USA"},{"name":"Department of Pediatrics Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minmin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Drogosz","sequence":"additional","affiliation":[{"name":"Department of Cardiology Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Callahan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Boston Children's Hospital  Boston Massachusetts USA"},{"name":"Department of Pediatrics Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey C.","family":"Marshall","sequence":"additional","affiliation":[{"name":"Department of Cardiology Boston Children's Hospital  Boston Massachusetts USA"},{"name":"Department of Pediatrics Harvard Medical School  Boston Massachusetts USA"},{"name":"The Hospital for Sick Children University of Toronto School of Medicine  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron R.","family":"Prosnitz","sequence":"additional","affiliation":[{"name":"Department of Cardiology Boston Children's Hospital  Boston Massachusetts USA"},{"name":"Department of Pediatrics Harvard Medical School  Boston Massachusetts USA"},{"name":"Sanger Heart and Vascular Institute Levine Children's Hospital  Charlotte North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terra","family":"Lafranchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol B.","family":"Benson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise E.","family":"Wilkins\u2010Haug","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne","family":"Tworetzky","sequence":"additional","affiliation":[{"name":"Department of Cardiology Boston Children's Hospital  Boston Massachusetts USA"},{"name":"Department of Pediatrics Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(89)90226-X"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(92)90834-I"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.77.3.205"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.588194"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.6.1531"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15876"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.65.5.256"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)00733-5"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.848994"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5132"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000144357.29279.54"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.009032"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17530"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.04.055"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2732"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e318123fd3a"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.11.005"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5232"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.18913"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.5885","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pd.5885","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.5885","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T11:16:40Z","timestamp":1693567000000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.5885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,2]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1002\/pd.5885"],"URL":"https:\/\/doi.org\/10.1002\/pd.5885","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,2]]},"assertion":[{"value":"2020-09-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}