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Other anatomic abnormalities are seen in approximately 50% of cases, most notably cardiac defects (19%\u201332%). Approximately, 50% of cases are associated with genetic and multiple malformation syndromes including trisomy 13\/18, pentalogy of Cantrell and Beckwith\u2013Wiedemann syndrome. Therefore, a thorough evaluation is recommended, including detailed anatomic survey, fetal echocardiogram, genetic counseling, and prenatal diagnostic testing. Overall prognosis depends on the size of the omphalocele, genetic studies, and associated anomalies. Early prenatal diagnosis remains important in order to provide parental counseling and assist in pregnancy management. Delivery should occur at a tertiary care center. Timing and mode of delivery should be based on standard obstetric indications with cesarean delivery reserved for large omphalocele (&gt;5\u00a0cm) or those that involve the fetal liver. Neonatal management involves either primary or staged reduction, both of which can be associated with a prolonged neonatal hospitalization.<\/jats:p>","DOI":"10.1002\/pd.5886","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T10:04:39Z","timestamp":1610705079000},"page":"486-496","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Omphalocele\u2014What should we tell the prospective parents?"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7776-2941","authenticated-orcid":false,"given":"April D.","family":"Adams","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Division of Maternal Fetal Medicine Baylor College of Medicine  Houston Texas USA"},{"name":"Department of Molecular and Human Genetics Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Stover","sequence":"additional","affiliation":[{"name":"Department of Molecular and Human Genetics Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0673-8845","authenticated-orcid":false,"given":"Martha W.","family":"Rac","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Division of Maternal Fetal Medicine Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,4]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"833","volume-title":"Fetology: Diagnosis and management of the fetal patient","author":"Bianchi DW","year":"2010"},{"key":"e_1_2_6_3_1","first-page":"496","volume-title":"Diagnostic imaging: Obstetrics","author":"Woodward 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