{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T16:31:31Z","timestamp":1784910691618,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T00:00:00Z","timestamp":1612483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the clinical significance of brain germinal matrix (GM) changes in cytomegalovirus (CMV) infected fetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This is a retrospective analysis. Group A; isolated GM finding, with or without lenticulostriatal vasculopathy (LSV). Group B; non\u2010isolated lesion. Amniocentesis, urinalysis, postnatal US and developmental assessment, were obtained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Group A and B included 18 and four fetuses, respectively. In group A, mean fetal age at diagnosis was 34.3\u00a0weeks (31\u201338\u00a0weeks). In 15\/18 (83.3%), the lesion was bilateral and LSV was present in 8\/18 (44.4%). Small cysts appeared inside the lesion in 5\/18 (27.7%). MRI was normal in 8\/18 (44.4%). Subtle or inconclusive findings were reported in the remaining fetuses. Brain ultrasound was normal in 10\/18 (55.5%) of newborns. In the remaining, caudothalamic cyst with or without LSV, or isolated LSV were found. All newborns are developing normally at a mean follow\u2010up age of 33.3\u00a0months (+\/\u2212 19.6 moths). In group B, all four patients requested for termination of pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fetal CMV infection may cause focal GM changes, frequently accompanied by LSV, late in pregnancy. These changes may be isolated, or as part of a more generalized brain damage. When isolated, favorable prognosis is expected.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5888","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T14:59:09Z","timestamp":1610722749000},"page":"877-883","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A unique brain germinal matrix involvement in cytomegalovirus infected fetuses: A retrospective neurosonographic analysis with outcome correlation"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1073-6348","authenticated-orcid":false,"given":"Roee","family":"Birnbaum","sequence":"first","affiliation":[{"name":"OB\u2010GYN Ultrasound Unit Lis Maternity Hospital Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi","family":"Winsteen","sequence":"additional","affiliation":[{"name":"OB\u2010GYN Ultrasound Unit Lis Maternity Hospital Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Brusilov","sequence":"additional","affiliation":[{"name":"OB\u2010GYN Ultrasound Unit Lis Maternity Hospital Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igal","family":"Wolman","sequence":"additional","affiliation":[{"name":"OB\u2010GYN Ultrasound Unit Lis Maternity Hospital Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liat","family":"Ben\u2010Sira","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel\u2010Aviv Israel"},{"name":"Tel Aviv Sourasky Medical Center Pediatric Radiology Unit  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Malinger","sequence":"additional","affiliation":[{"name":"OB\u2010GYN Ultrasound Unit Lis Maternity Hospital Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9868-3548","authenticated-orcid":false,"given":"Karina","family":"Krajden Haratz","sequence":"additional","affiliation":[{"name":"OB\u2010GYN Ultrasound Unit Lis Maternity Hospital Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.535"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.544"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.21991"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000446690"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.03.052"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5634"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4118"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5180"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2694"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.11.032"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5591"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12377"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15935"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1201\/9780203507483"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2016.00011"},{"issue":"2","key":"e_1_2_7_17_1","first-page":"382","article-title":"Volumetric analysis of the germinal matrix and lateral ventricles performed using MR images of postmortem fetuses","volume":"22","author":"Kinoshita Y","year":"2001","journal-title":"Am J Neuroradiol."},{"key":"e_1_2_7_18_1","volume-title":"Pediatric Neuroimaging 6th Ed","author":"Barkovich A. James","year":"2018"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2013.796169"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-015-1622-5"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20236"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3508"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-020-0780-2"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-018-0630-5"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1969"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1369521"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000116737"},{"issue":"2","key":"e_1_2_7_28_1","first-page":"219","article-title":"Human germinal matrix: venous origin of hemorrhage and vascular characteristics","volume":"18","author":"Ghazi\u2010Birry HS","year":"1997","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1962.04210050022004"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2012-303223"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00840.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4916"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14820"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.914"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.5888","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pd.5888","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.5888","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T15:50:10Z","timestamp":1693410610000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.5888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,5]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/pd.5888"],"URL":"https:\/\/doi.org\/10.1002\/pd.5888","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,5]]},"assertion":[{"value":"2020-09-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}