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While triploidy and genome\u2010wide uniparental disomy can be ascribed to fertilization or meiotic errors, the mechanisms causing mixoploidy and chimerism remain shrouded in mystery. Different models have been proposed, but all remain hypothetical and controversial, are deduced from the developmental persistent genomic constitutions present in the sample studied and lack direct evidence. New single\u2010cell genomic methodologies, such as single\u2010cell genome\u2010wide haplotyping, provide an extended view of the constitution of normal and abnormal embryos and have further pinpointed the existence of mixoploidy in cleavage\u2010stage embryos. Based on those recent findings, we suggest that genome\u2010wide anomalies, which persist in fetuses and patients, can for a large majority be explained by a noncanonical first zygotic cleavage event, during which maternal and paternal genomes in a single zygote, segregate to different blastomeres. This process, termed heterogoneic division, provides an overarching theoretical basis for the different presentations of mixoploidy and chimerism.<\/jats:p>","DOI":"10.1002\/pd.5895","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T10:08:12Z","timestamp":1610705292000},"page":"554-563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Genome\u2010wide abnormalities in embryos: Origins and clinical consequences"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0215-8990","authenticated-orcid":false,"given":"Heleen","family":"Masset","sequence":"first","affiliation":[{"name":"Department of Human Genetics Laboratory for Cytogenetics and Genome Research KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"T\u0161uiko","sequence":"additional","affiliation":[{"name":"Department of Human Genetics 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