{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:48:11Z","timestamp":1747151291917,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T00:00:00Z","timestamp":1611532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Identify placental pathology\u2010related complications, labor and neonatal outcomes in pregnancies complicated by pathological nuchal translucency (NT) with normal microarray analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study in which all women with singleton pregnancy who demonstrated NT above 3\u00a0mm and a normal microarray analysis were matched to women with normal NT and a normal microarray analysis (2013\u20132019) in a single tertiary academic center. The following placental pathology\u2010related parameters were measured: preeclampsia, oligohydramnios, suspected intrauterine growth restriction, abnormal Doppler studies or small for gestational age (SGA) neonates. The primary outcome was defined as a composite of complications related to placental pathology including preeclampsia and SGA neonate. Secondary outcomes were labor complications and neonatal morbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 185 women were included in the study: of them, 47 presented an abnormal NT (study group) and 138 presented normal NT (controls). Groups did not significantly differ in baseline characteristics. Regarding primary outcome, all placental\u2010related complications frequencies were higher in the study group<jats:italic>,<\/jats:italic> with a composite rate of 17.02% versus 6.52% in controls (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.042%). Secondary outcomes did not differ between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Abnormal NT measurement presented in pregnancies with normal fetal microarray analysis is associated with higher rates of placental\u2010related complications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5896","type":"journal-article","created":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T02:49:06Z","timestamp":1609901346000},"page":"855-860","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Abnormal nuchal translucency followed by normal microarray analysis is associated with placental pathology\u2010related complications"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5859-9528","authenticated-orcid":false,"given":"Eyal","family":"Krispin","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Rabin Medical Center Helen Schneider Hospital for Women  Petach Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Obstetrics and Gynecology Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anya","family":"Kushnir","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asaf","family":"Shemer","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shlomit","family":"Rienstein","sequence":"additional","affiliation":[{"name":"The Danek Gertner Institute of Human Genetics Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Berkenstadt","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"The Danek Gertner Institute of Human Genetics Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0702-370X","authenticated-orcid":false,"given":"Yoav","family":"Yinon","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Obstetrics and Gynecology Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boaz","family":"Weisz","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Obstetrics and Gynecology Sheba Medical Center  Tel Hashomer 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