{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:43:39Z","timestamp":1790671419025,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T00:00:00Z","timestamp":1614297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The limited number of large fetal cohort studies on common arterial trunk (CAT) impedes prenatal counseling at midgestation. This study evaluates the prognosis of CAT from a fetal perspective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Fetuses with a prenatally diagnosed CAT were extracted from the PRECOR registry (2002\u20132016). We evaluated fetal and postnatal survival and the presence of additional morbidity at last follow\u2010up. Literature databases were searches systematically for additional cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010eight cases with a prenatal diagnosis of CAT were identified in our registry, of which 18\/38 (47%) opted for pregnancy termination (TOP). Two cases resulted in spontaneous intrauterine demise (10%, 2\/20), six cases demised postnatally (33%, 6\/18), leaving 60% (12\/20) alive, after exclusion of TOP, at a mean age of six (range: 2\u201310\u00a0years).<\/jats:p><jats:p>Additional morbidity was found in 42% (5\/12) of survivors, including 22q11.2 deletion syndrome, Adams\u2010Oliver syndrome and intestinal atresia, whereas 8% (1\/12) had developmental delay. The remaining 30% (6\/12) of survivors appeared isolated with normal development. All of whom six required replacement of the initial right ventricle to pulmonary artery conduit. Additionally, we reviewed 197 literature cases on short\u2010term outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The risk of fetal and neonatal demise, as well as significant morbidity amongst survivors, should be included in prenatal counseling for CAT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5907","type":"journal-article","created":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T22:22:44Z","timestamp":1611354164000},"page":"754-765","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The prognosis of common arterial trunk from a fetal perspective: A prenatal cohort study and systematic literature review"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1752-5834","authenticated-orcid":false,"given":"Amber E. L.","family":"van Nisselrooij","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Fetal Medicine Leiden University Medical Center  Leiden Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotta","family":"Herling","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Center for Fetal Medicine Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally\u2010Ann","family":"Clur","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology Emma Children's Hospital Academic Medical Center Amsterdam UMC  Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingeborg H.","family":"Linskens","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Amsterdam Reproduction and Development Research Institute, Amsterdam University Medical Center  Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Pajkrt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Amsterdam Reproduction and Development Research Institute, Amsterdam University Medical Center  Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas A.","family":"Rammeloo","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology Emma Children's Hospital Academic Medical Center Amsterdam UMC  Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arend D. 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