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The primary outcome was neurodevelopmental delay. Secondary outcomes included, motor skills, intelligence, vision, hearing, language and behavior abnormalities.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Thirteen out of 87 (15%) studies reported on isolated CDH, including 2624 out of 24,146 children. Neurodevelopmental delay was investigated in four studies and found to be present in 16% (3\u201034%) of children. This was mainly attributed to motor problems in 13% (2\u201030%), whereas cognitive dysfunction only in 5% (0\u201020%) and hearing in 3% (1\u20107%). One study assessed the effect of fetal surgery. When both isolated and non\u2010isolated children were included, these numbers were higher.<\/jats:p><jats:p><jats:bold>Discussion:<\/jats:bold> This systematic review demonstrates that only a minority of studies focused on isolated CDH, with neurodevelopmental delay present in 16% of children born with CDH.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> To accurately counsel patients, more research should focus on isolated CDH cases and examine children that underwent fetal surgery.<\/jats:p>","DOI":"10.1002\/pd.5916","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T23:25:37Z","timestamp":1612567537000},"page":"318-329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Neurodevelopmental outcomes in children with isolated congenital diaphragmatic hernia: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6551-661X","authenticated-orcid":false,"given":"Lennart","family":"Van der Veeken","sequence":"first","affiliation":[{"name":"Department of Development and Regeneration, Cluster Woman and Child Group Biomedical Sciences KU Leuven University of Leuven  Leuven Belgium"},{"name":"Department of Obstetrics and Gynaecology University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simen","family":"Vergote","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration, Cluster Woman and Child Group Biomedical Sciences KU Leuven University of Leuven  Leuven Belgium"},{"name":"Department of Obstetrics and Gynaecology University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7388-1414","authenticated-orcid":false,"given":"Yada","family":"Kunpalin","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration, Cluster Woman and Child Group Biomedical Sciences KU Leuven University of Leuven  Leuven Belgium"},{"name":"Institute for Women's Health University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Copenhagen University Hospital  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4920-945X","authenticated-orcid":false,"given":"Jan","family":"Deprest","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration, Cluster Woman and Child Group Biomedical Sciences KU Leuven University of Leuven  Leuven Belgium"},{"name":"Department of Obstetrics and Gynaecology University Hospitals Leuven  Leuven Belgium"},{"name":"Institute for Women's Health University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4775-872X","authenticated-orcid":false,"given":"Matteo","family":"Bruschettini","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Lund University Sk\u00e5ne University Hospital  Lund Sweden"},{"name":"Cochrane Sweden Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,21]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"EUROCAT. 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