{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:48:15Z","timestamp":1747151295943,"version":"3.40.5"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002865","name":"Chongqing Science and Technology Commission","doi-asserted-by":"publisher","award":["cstc2017jcyjBX0045"],"award-info":[{"award-number":["cstc2017jcyjBX0045"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81520108013","81771613, 81671527"],"award-info":[{"award-number":["81520108013","81771613, 81671527"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Twin\u2010twin transfusion syndrome (TTTS) causes perinatal mortality and morbidity in monochorionic twins. The early recognition of and interventional therapy for TTTS is associated with a more favorable overall prognosis. However, the prediction by the use of ultrasound in the first trimester has relatively poor sensitivity and specificity. This study aimed to identify metabolic biomarkers to aid in ultrasound screening of TTTS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Maternal plasma was prospectively collected between 11 and 15\u00a0weeks of gestation in apparently uncomplicated monochorionic\u2010diamniotic twin pregnancies. This cohort was divided into: (i) patients who were subsequently diagnosed with TTTS by using ultrasound; (ii) uncomplicated matched controls. Metabolome was profiled by using gas chromatography\u2010mass spectrometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The levels of fatty acids, organic acids, oxaloacetic acid, and beta\u2010alanine were significantly lower in the TTTS maternal plasma at 11\u201315\u00a0weeks of gestation, and methionine and glycine were also higher (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05, FDR&lt;0.12). Generally, in TTTS pregnancies, the metabolisms of amino acid, carbohydrate, cofactors, vitamins, and purine were \u201cdown\u2010regulated\u201d; whereas bile secretion and pyrimidine metabolism were \u201cupregulated.\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The metabolomics scanning of early gestation maternal plasma may identify those pregnancies that subsequently develop TTTS; in particular, downregulated fatty acid levels may be biologically plausible to be implicated in the pathogenesis of TTTS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5933","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T15:08:04Z","timestamp":1615820884000},"page":"1080-1088","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Twin\u2010twin transfusion syndrome is associated with alterations in the metabolic profile of maternal plasma in early gestation: a pilot study"],"prefix":"10.1002","volume":"41","author":[{"given":"Yang","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Obstetrics The First Affiliated Hospital of Chongqing Medical University  Chongqing China"},{"name":"International Collaborative Laboratory of Reproduction and Development, Ministry of Education Chongqing Medical University  Chongqing China"},{"name":"State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics The First Affiliated Hospital of Chongqing Medical University  Chongqing China"},{"name":"International Collaborative Laboratory of Reproduction and Development, Ministry of Education Chongqing Medical University  Chongqing China"},{"name":"State Key Laboratory of Maternal and Fetal Medicine 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Chongqing Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Saffery","sequence":"additional","affiliation":[{"name":"Cancer, Disease and Developmental Epigenetics Murdoch Children's Research Institute  Parkville Victoria Australia"},{"name":"Department of Pediatrics University of Melbourne  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0828-2674","authenticated-orcid":false,"given":"Chao","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics The First Affiliated Hospital of Chongqing Medical University  Chongqing China"},{"name":"International Collaborative Laboratory of Reproduction and Development, Ministry of Education Chongqing Medical University  Chongqing China"},{"name":"State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junnan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics The First Affiliated Hospital of Chongqing Medical University  Chongqing China"},{"name":"International Collaborative Laboratory of Reproduction and Development, Ministry of Education Chongqing Medical University  Chongqing China"},{"name":"State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbo","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics The First Affiliated Hospital of Chongqing Medical University  Chongqing China"},{"name":"International Collaborative Laboratory of Reproduction and Development, Ministry of Education Chongqing Medical University  Chongqing China"},{"name":"State Key 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