{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T13:13:01Z","timestamp":1782825181860,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T00:00:00Z","timestamp":1617580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report our experience with targeted scans of the fetal pancreas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Targeted scans were performed in 16 cases referred for anatomical or genetic conditions associated with structural pancreatic malformations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four fetuses were evaluated for nephromegaly and macroglossia. In three of them, the pancreas circumference was &gt;90th percentile. Genetic testing revealed Beckwith\u2013Wiedemann syndrome. In the fourth case, the pancreas circumference was normal; exome sequencing revealed two heterozygous <jats:italic>ETFDH<\/jats:italic> gene mutations consistent with glutaric acidemia type II. In a case referred for non\u2010visualization of the gallbladder, the fetal pancreas was not visualized and genetic analysis revealed a mutation in the <jats:italic>ONECUT1<\/jats:italic> gene encoding for <jats:italic>HNF6<\/jats:italic>. Targeted scan for heterotaxia revealed three cases with variable degrees of agenesis of the pancreas, one case with a normally structured right sided pancreas and one case with a normal pancreas. Cases referred following a genetic diagnosis included a case of maternal nesidioblastosis with an extremely large fetal pancreas; and five fetuses diagnosed with a <jats:italic>TCF2<\/jats:italic> deletion all with a normal pancreas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prenatal assessment of the fetal pancreas may be a significant factor in prenatal diagnosis and counselling in cases presenting with anatomical and genetic conditions reported post\u2010natally to be associated with pancreatic structural and functional abnormalities.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5939","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T05:00:18Z","timestamp":1616994018000},"page":"828-834","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The diagnostic potential of targeted imaging of the fetal pancreas"],"prefix":"10.1002","volume":"41","author":[{"given":"Yinon","family":"Gilboa","sequence":"first","affiliation":[{"name":"Ultrasound Unit The Helen Schneider Women's Hospital Rabin Medical Center, Beilinson Campus  Petach Tikva Israel"},{"name":"Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4418-7551","authenticated-orcid":false,"given":"Rivka","family":"Sukenik\u2010Halevy","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Raphael Recanati Genetic Institute Rabin Medical Center, Beilinson Campus  Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eran","family":"Kassif","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Obstetrics and Gynecology Prenatal Diagnostic Unit The 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