{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T21:03:17Z","timestamp":1788555797961,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["WT101957"],"award-info":[{"award-number":["WT101957"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the incidence and characterise corpus callosum (CC) abnormalities in fetuses with spina bifida aperta (SBA) between 18 and 26 weeks of gestation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective study on fetuses with isolated SBA and who were assessed for fetal surgery. Digitally stored ultrasound images of the brain were reviewed for the presence\/absence of the CC, and the length and diameter of its constituent parts (rostrum, genu, body and splenium). We used regression analysis to determine the relationship between CC abnormalities and gestational age, head circumference, ventricle size, lesion level and lesion type.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nearly three\u2010quarters of fetuses with isolated SBA had an abnormal CC (71.7%, 76\/106). Partial agenesis was most common in the splenium (18.9%, 20\/106) and the rostrum (13.2%, 14\/106). The most common abnormal pattern was of a short CC with normal diameter throughout. Of note, 20.8% (22\/106) had a hypoplastic genu and 28.3% (30\/106) had a thick body part. Larger lateral ventricle size was associated with partial agenesis of the CC (odds ratio [OR]: 0.14,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and inversely associated with a shorter CC (OR: 2.60,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>An abnormal CC is common in fetuses with isolated SBA who are referred for fetal surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.5945","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T03:39:56Z","timestamp":1617075596000},"page":"957-964","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Incidence and patterns of abnormal corpus callosum in fetuses with isolated spina bifida aperta"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7388-1414","authenticated-orcid":false,"given":"Yada","family":"Kunpalin","sequence":"first","affiliation":[{"name":"Elizabeth Garrett Anderson Institute for Women's Health University College London  London UK"},{"name":"Department of Development and Regeneration Cluster Woman and Child, Biomedical Sciences, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4920-945X","authenticated-orcid":false,"given":"Jan","family":"Deprest","sequence":"additional","affiliation":[{"name":"Elizabeth Garrett Anderson Institute for Women's Health University College London  London UK"},{"name":"Department of Development and Regeneration Cluster Woman and Child, Biomedical Sciences, KU Leuven  Leuven Belgium"},{"name":"Department of Obstetrics and Gynaecology University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7969-1435","authenticated-orcid":false,"given":"Ioannis","family":"Papastefanou","sequence":"additional","affiliation":[{"name":"Fetal Medicine Clinic  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Bredaki","sequence":"additional","affiliation":[{"name":"Elizabeth Garrett Anderson Institute for Women's Health University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9182-9628","authenticated-orcid":false,"given":"Adalina","family":"Sacco","sequence":"additional","affiliation":[{"name":"Elizabeth Garrett Anderson Institute for Women's Health University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5029-7899","authenticated-orcid":false,"given":"Francesca","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration Cluster Woman and Child, Biomedical Sciences, KU Leuven  Leuven Belgium"},{"name":"Department of Obstetrics and Gynaecology University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jute","family":"Richter","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration Cluster Woman and Child, Biomedical Sciences, KU Leuven  Leuven Belgium"},{"name":"Department of Obstetrics and Gynaecology University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrien","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration Cluster Woman and Child, 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