{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:24:34Z","timestamp":1789179874922,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the historical aspects, current availability, and clinical outcomes of open intrauterine repair of spina bifida aperta (IRSBA) in Spanish\u2010speaking Latin American countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cases were collected from centers with at least 2 years of experience and a minimum of 10 open IRSBA interventions by December 2020. Clinical variables were compared to the results of the Management of Myelomeningocele Study (MOMS) trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Clinical experience with 314 cases from seven centers was reviewed. Most cases (<jats:italic>n<\/jats:italic>\u00a0=\u00a0189, 60.2%) were performed between 24 and 25.9 weeks' gestation. Delivery at less than 30 weeks' gestation occurred in 36 cases (11.5%) and the overall perinatal mortality rate was 5.4% (17 of 314). The rate of maternal complications was low, including the need for blood transfusion (<jats:italic>n<\/jats:italic>\u00a0=\u00a03, 0.9%) and dehiscence or a thin uterine scar (<jats:italic>n<\/jats:italic>\u00a0=\u00a04, 1.3%). No cases of maternal death were recorded. Fifteen neonates required additional surgical repair of the spinal defect (4.8%) and 63 of 167 infants (37.7%) required a cerebrospinal fluid diversion procedure. Only two of the seven centers reported preliminary experience with fetoscopic IRSBA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Clinical experience and outcomes were within the expected results reported by the MOMS trial. There is still very limited experience with fetoscopic IRSBA in this part of the world.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5994","type":"journal-article","created":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T17:28:45Z","timestamp":1624814925000},"page":"933-941","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Open intrauterine repair of spina bifida aperta: Historical aspects, current availability, and clinical outcomes from the Latin American Spina Bifida Consortium"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3856-574X","authenticated-orcid":false,"given":"Waldo","family":"Sepulveda","sequence":"first","affiliation":[{"name":"FETALMED\u2013Maternal\u2010Fetal Diagnostic Center Santiago Chile"},{"name":"Clinica Las Condes Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5999-866X","authenticated-orcid":false,"given":"Rogelio","family":"Cruz\u2010Martinez","sequence":"additional","affiliation":[{"name":"Hospital San Jose and Hospital de Especialidades del Ni\u00f1o y la Mujer Queretaro Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6241-0596","authenticated-orcid":false,"given":"Adolfo","family":"Etchegaray","sequence":"additional","affiliation":[{"name":"Hospital Universitario Austral Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0720-9248","authenticated-orcid":false,"given":"Jose","family":"Sanin\u2010Blair","sequence":"additional","affiliation":[{"name":"Clinica Universitaria Bolivariana Medellin Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2888-1394","authenticated-orcid":false,"given":"Walter","family":"Ventura","sequence":"additional","affiliation":[{"name":"Instituto Nacional Materno\u2010Perinatal Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0128-7210","authenticated-orcid":false,"given":"Edgardo","family":"Corral","sequence":"additional","affiliation":[{"name":"Hospital Regional Rancagua Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7531-8927","authenticated-orcid":false,"given":"Rolando","family":"Marquez","sequence":"additional","affiliation":[{"name":"Hospital Carlos van Buren Valparaiso Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17445-X"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30057"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.7"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31872"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980013000256"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000364806"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-017-3445-7"},{"key":"e_1_2_9_9_1","first-page":"151","volume-title":"Fetology: Diagnosis and Management of the Fetal Patient","author":"Bianchi DW","year":"2010"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014379"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001296"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5383"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-017-3444-8"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15312"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5675"},{"key":"e_1_2_9_16_1","first-page":"326","article-title":"Fetal surgery: current state [in Spanish]","volume":"9","author":"Martinez Ferro M","year":"2002","journal-title":"Med Infant"},{"key":"e_1_2_9_17_1","volume-title":"Proceeding of the 71st Annual Meeting of the American Association of Neurological Surgeons","author":"Alvarez CA","year":"2003"},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.61651\/rped.2004v57n2p63-65","article-title":"Prenatal repair of myelomeningocele [in Spanish]","volume":"57","author":"Alvarez CE","year":"2004","journal-title":"Rev Peru Pediatr"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000089060"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-006-0169-5"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000093882"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-011-1662-z"},{"key":"e_1_2_9_23_1","first-page":"56","article-title":"Fetal surgery: intrauterine repair of myelomeningocele. 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