{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:20:39Z","timestamp":1790828439798,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:00:00Z","timestamp":1628121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim of the study<\/jats:title><jats:p>Outcome of fetuses, prenatally diagnosed with sacrococcygeal teratoma (SCT), is still poorly documented. This study assesses the incidence and prenatal predictors of outcome in all fetuses prenatally diagnosed with SCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective study on all fetuses prenatally diagnosed with SCT from 1998 to 2018 in the Netherlands. Poor outcome was defined as terminations of pregnancy (TOP) because of expected unfavorable outcome, intrauterine fetal death, or early neonatal death. Potential risk factors for poor outcome were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main results<\/jats:title><jats:p>Eighty\u2010four fetuses were included. Sixteen (19.0%) TOPs were excluded from statistical analysis. Eleven of the remaining 68 fetuses had poor outcome. Overall mortality was 32.1%, with a mortality excluding TOPs of 13.1%. Thirteen fetal interventions were performed in 11 (13.1%) fetuses. Potential risk factors for poor outcome were the presence of fetal hydrops (OR: 21.0, CI: 2.6\u2013275.1, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.012) and cardiomegaly (OR: 10.3, CI: 1.9\u201355.8, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.011).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The overall mortality of fetuses prenatally diagnosed with SCTs including tTOP was 32.1%. This high mortality rate was mainly due to termination of pregnancy. Mortality excluding TOP was 13.1%. Potential risk factors for poor outcome were fetal hydrops and cardiomegaly.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6026","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T08:14:23Z","timestamp":1627632863000},"page":"1430-1438","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Factors associated with poor outcome in fetuses prenatally diagnosed with sacrococcygeal teratoma"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3877-1698","authenticated-orcid":false,"given":"Lieke J.","family":"van Heurn","sequence":"first","affiliation":[{"name":"Department of P(a)ediatric Surgery Emma Children's Hospital Amsterdam UMC University of Amsterdam\u00a0&amp; Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey B. C.","family":"Coumans","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Maastricht UMC +  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joep P. M.","family":"Derikx","sequence":"additional","affiliation":[{"name":"Department of P(a)ediatric Surgery Emma Children's Hospital Amsterdam UMC University of Amsterdam\u00a0&amp; Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireille N.","family":"Bekker","sequence":"additional","affiliation":[{"name":"Department of Obstetrics University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia M.","family":"Bilardo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Amsterdam University Medical Centers  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie K.","family":"Duin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynaecology and Prenatal Diagnosis University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten F. C. M.","family":"Knapen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Fetal Medicine Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Pajkrt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Amsterdam UMC University of Amsterdam\u00a0&amp; Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Sikkel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Radboud University Medical Center Nijmegen  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. W. Ernest","family":"van Heurn","sequence":"additional","affiliation":[{"name":"Department of P(a)ediatric Surgery Emma Children's Hospital Amsterdam UMC University of Amsterdam\u00a0&amp; Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick","family":"Oepkes","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Fetal Medicine Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2007.01.050"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(98)90426-2"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-002-0884-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.05.019"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2016.07.005"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.10.022"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2122"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2011.08.020"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2003.11.005"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(92)90282-C"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000093884"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(86)80404-3"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2004.08.031"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.05.009"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(90)90535-H"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2015.02.034"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2014.01.036"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(00)90032-0"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(98)90670-4"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.14553"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2013.03.016"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2011.03.051"},{"key":"e_1_2_8_24_1","volume-title":"Geboorte; kerncijfers","author":"Centraal Bureau voor de Statistiek","year":"2019"},{"key":"e_1_2_8_25_1","volume-title":"Begeleiding bij foetale sterfte en doodgeboorte","author":"Nederlandse Vereniging voor Obstetrie en Gynaecologie Richtlijn","year":"2014"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(74)80297-6"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2006.00678.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2015.09.007"},{"issue":"6","key":"e_1_2_8_29_1","first-page":"e251\u20106","article-title":"High prevalence of sacrococcygeal teratoma in Finland \u2013 a nationwide population\u2010based study","volume":"102","author":"Pauniaho SL","year":"1992","journal-title":"Acta Paediatr"},{"key":"e_1_2_8_30_1","unstructured":"Rijkstinstituut voor Volksgezondheid en Milieu. 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