{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:33:44Z","timestamp":1793414024157,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T00:00:00Z","timestamp":1629936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G080217N"],"award-info":[{"award-number":["G080217N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cancer is diagnosed in one in 1000 to 1500 pregnancies. Most frequently encountered malignancies during pregnancy are breast cancer, hematological cancer, cervical cancer and malignant melanoma. Maternal cancer is associated with an increased risk of IUGR and preterm labor, especially in patients with systemic disease or those receiving chemotherapy during pregnancy, requiring a high\u2010risk obstetrical follow\u2010up. Fetal aneuploidy screening by non\u2010invasive prenatal testing (NIPT) can lead to the incidental identification of copy number alterations derived from non\u2010fetal cell\u2010free DNA (cfDNA), as seen in certain cases of maternal malignancy. The identification of tumor\u2010derived cfDNA requires further clinical, biochemical, radiographic and histological investigations to confirm the diagnosis. In such cases, reliable risk estimation for fetal trisomy 21, 18 and 13 is impossible. Therefore, invasive testing should be offered when ultrasonographic screening reveals an increased risk for chromosomal anomalies, or when a more accurate test is desired. When the fetal karyotype is normal, long term implications for the fetus refer to the consequences of the maternal disease and treatment during pregnancy. This manuscript addresses parental questions when NIPT suggests a maternal malignancy. Based on current evidence and our own experience, a clinical management scheme in a multidisciplinary setting is proposed.<\/jats:p>","DOI":"10.1002\/pd.6031","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T23:45:59Z","timestamp":1629243959000},"page":"1264-1272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Non\u2010invasive prenatal testing suggesting a maternal malignancy: What do we tell the prospective parents in Belgium?"],"prefix":"10.1002","volume":"41","author":[{"given":"Lore","family":"Lannoo","sequence":"first","affiliation":[{"name":"Department of Development and Regeneration, Division Woman and Child Clinical Department Obstetrics and Gynaecology University Hospital Leuven, KULeuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liesbeth","family":"Lenaerts","sequence":"additional","affiliation":[{"name":"Department of 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