{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:44:03Z","timestamp":1788263043658,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2021,9,19]],"date-time":"2021-09-19T00:00:00Z","timestamp":1632009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Neurodevelopmental delay is more common in children born with congenital heart defects (CHD), even with optimal perinatal and peri\u2010operative care. It is hypothesized that fetuses with CHD are prone to neurological impairment in utero due to their cardiac defect, possibly leading to delayed cortical development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cerebral cortical maturation was assessed with advanced neurosonographic examinations every 4 weeks in fetuses with CHD and compared to control fetuses. Five different primary fissures and four areas were scored (ranging 0\u20135) by blinded examiners using a cortical maturation scheme.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cortical staging was assessed in 574 ultrasound examinations in 85 CHD fetuses and 61 controls. Small differences in grading were seen in Sylvian and cingulate fissures. (Sylvian fissure: \u22120.12 grade, 95% CI (\u22120.23; \u22120.01) <jats:italic>p<\/jats:italic>\u00a0=\u00a00.05, cingulate fissure: \u22120.24 grade, 95% CI (\u22120.38; \u22120.10) <jats:italic>p<\/jats:italic> = &lt;0.001. Other cortical areas showed normal maturation as compared to control fetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Small differences were seen in three of the nine analyzed cortical areas in CHD fetuses, in contrast to previous reports on progressive third\u2010trimester delay. The clinical implications of the small differences however, remain unknown.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6038","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T23:24:13Z","timestamp":1630625053000},"page":"1649-1657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Serial neurosonography in fetuses with congenital heart defects shows mild delays in cortical development"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0653-1841","authenticated-orcid":false,"given":"Sheila M.","family":"Everwijn","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Prenatal Diagnosis Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiska F.","family":"van Bohemen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology HAGA Hospital  The Hague The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"van Geloven","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Sciences Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5258-1957","authenticated-orcid":false,"given":"Fenna A.","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Prenatal Diagnosis Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aalbertine K.","family":"Teunissen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Prenatal Diagnosis Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieke","family":"Rozendaal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Blom","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan M.","family":"van Lith","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Prenatal Diagnosis Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique C.","family":"Haak","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Prenatal Diagnosis Leiden University Medical Center  Leiden The 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